Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death.

Sönmez Ünal G, Albak Y, Yurtcu N, Yıldız Ç, Çetin M, Durna Daştan S, Gümüş E, Çetin A

Turkish journal of obstetrics and gynecology1 Sept 2023Cited by 3 (Europe PMC)

PMID37667560PMCIDPMC10478719DOI10.4274/tjod.galenos.2023.85616PepBankPUB-37667560

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, ganirelix day 1 significantly reduced Beclin2 gene expression versus control.
In plain wordsIn mice with endometriosis, ganirelix reduced Beclin2 expression compared with control.
Peptide
Ganirelix
Outcome
DecreaseBeclin2 expression on day 1
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Control
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Beclin2 gene expression coefficients of metformin 1^st day, metformin 7^th day, ganirelix 1^st day, and general 7^th day groups were found to have significantly decreased compared with the control group coefficient.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756001
02AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, ganirelix day 1 significantly reduced Beclin1 gene expression versus control.
In plain wordsIn mice with endometriosis, ganirelix reduced Beclin1 expression compared with control.
Peptide
Ganirelix
Outcome
DecreaseBeclin1 expression on day 1
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Control
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Beclin1 gene expression coefficients of metformin 1^st day, metformin 7^th day, ganirelix 1^st day, and genirelix 7^th day groups were found to have significantly decreased compared with the control group coefficient.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756002
03AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, ganirelix day 7 significantly reduced Beclin1 gene expression versus control.
In plain wordsIn mice with endometriosis, ganirelix reduced Beclin1 expression compared with control.
Peptide
Ganirelix
Outcome
DecreaseBeclin1 expression on day 7
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Control
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Beclin1 gene expression coefficients of metformin 1^st day, metformin 7^th day, ganirelix 1^st day, and genirelix 7^th day groups were found to have significantly decreased compared with the control group coefficient.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756003
04AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, LC3BII expression was significantly higher with ganirelix day 1 than metformin day 1.
In plain wordsIn mice with endometriosis, LC3BII expression was higher with ganirelix than metformin.
Peptide
Ganirelix
Outcome
IncreaseLC3BII expression on day 1 versus metformin day 1
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Metformin day 1
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LC3BII gene expression coefficients of metformin 1^st day and metformin 7^th day groups were found to have significantly decreased compared with LC3BII gene expression coefficients of control, genirelix 1^st day, and genirelix 7^th day groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756004
05AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, LC3BII expression was significantly higher with ganirelix day 1 than metformin day 7.
In plain wordsIn mice with endometriosis, LC3BII expression was higher with ganirelix than metformin.
Peptide
Ganirelix
Outcome
IncreaseLC3BII expression on day 1 versus metformin day 7
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Metformin day 7
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LC3BII gene expression coefficients of metformin 1^st day and metformin 7^th day groups were found to have significantly decreased compared with LC3BII gene expression coefficients of control, genirelix 1^st day, and genirelix 7^th day groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756005
06AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, LC3BII expression was significantly higher with ganirelix day 7 than metformin day 1.
In plain wordsIn mice with endometriosis, LC3BII expression was higher with ganirelix than metformin.
Peptide
Ganirelix
Outcome
IncreaseLC3BII expression on day 7 versus metformin day 1
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Metformin day 1
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LC3BII gene expression coefficients of metformin 1^st day and metformin 7^th day groups were found to have significantly decreased compared with LC3BII gene expression coefficients of control, genirelix 1^st day, and genirelix 7^th day groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756006
07AnimalAnimal study (in vivo)Mechanism
In mice with endometriosis, LC3BII expression was significantly higher with ganirelix day 7 than metformin day 7.
In plain wordsIn mice with endometriosis, LC3BII expression was higher with ganirelix than metformin.
Peptide
Ganirelix
Outcome
IncreaseLC3BII expression on day 7 versus metformin day 7
Study
mousen: not reported in source
Subcutaneous endometriosis
Comparator
Metformin day 7
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
LC3BII gene expression coefficients of metformin 1^st day and metformin 7^th day groups were found to have significantly decreased compared with LC3BII gene expression coefficients of control, genirelix 1^st day, and genirelix 7^th day groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This study aimed to investigate the efficacy of metformin and ganirelix on subcutaneous endometriotic tissues created in an experimental mouse model.
Summary · context
Gene expression coefficients of control, metformin day 1 (Met1g), metformin day 7 (Met7g), ganirelix day 1 (Gnx1g), and ganirelix day 7 (Gnx7g) groups are shown in tables.
Report a problemFND-3766756007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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Keywords

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