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Study · Systematic review · 2023

2 results

Treatment Efficacy of Pharmacotherapies for Frontotemporal Dementia: A Network Meta-Analysis of Randomized Controlled Trials.

Huang MH, Zeng BS, Tseng PT, Hsu CW, Wu YC, Tu YK, Stubbs B, Carvalho AF, Liang CS, Chen TY, Chen YW, Su KP

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry6 Jul 2023Cited by 6 (Europe PMC)

PMID37633762 (opens in a new tab)DOI10.1016/j.jagp.2023.06.013 (opens in a new tab)PepBankPUB-37633762
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In patients with frontotemporal dementia, high-dose oxytocin was associated with the greatest improvement in neuropsychiatric symptoms compared with placebo.

    In plain wordsIn people with frontotemporal dementia, high-dose oxytocin was linked to the largest improvement in behavioral and mood symptoms compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseNeuropsychiatric symptoms, high-dose oxytocin versus placebo
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    72 international unitsAs given in this study (human).

    Measurements

    SMD
    −1.17 SMD
    high-dose oxytocin vs placebo

    Source sentences

    Summary
    Compared with placebo, high-dose oxytocin (72 international units) was associated with the greatest improvement in patients' neuropsychiatric symptoms (SMD = -1.17, 95% CIs = -2.25 to -0.08, z = -2.10, p = 0.035).
    2 context sentences
    Summary · context
    We systematically searched several databases from inception to April 30, 2022, for RCTs of drug therapy in patients with FTD and neuropsychiatric symptoms (primary outcome).
    Summary · context
    Seven RCTs with 243 participants were included.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome

    In patients with frontotemporal dementia, no pharmacological intervention in the network, oxytocin included, significantly benefited cognitive function.

    In plain wordsIn people with frontotemporal dementia, none of the drugs studied, including oxytocin, clearly improved thinking and memory.

    Peptide
    Oxytocin
    Outcome
    No significant changeCognitive function, all pharmacological interventions
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    No pharmacological intervention significantly benefited cognitive function.
    2 context sentences
    Summary · context
    We systematically searched several databases from inception to April 30, 2022, for RCTs of drug therapy in patients with FTD and neuropsychiatric symptoms (primary outcome).
    Summary · context
    Seven RCTs with 243 participants were included.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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