In mouse aorta assays, AICAR-induced relaxation was significantly impaired after high-fat feeding compared with standard feeding.
In plain wordsIn lab tests of mouse aortas, AICAR-induced relaxation was lower after high-fat feeding than standard feeding.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseAICAR-induced vascular relaxation with high-fat feeding
- Study
mousen: not reported in source
thoracic aorta from high-fat-fed and dietary intervention mice- Comparator
- Chow mice
- Outcome group
- Receptor activity and mechanism · Cardiovascular
Source sentences
Relaxant responses to acetylcholine and the AMPK activator (AICAR) were significantly impaired in HF mice but improved in HF-Chow mice.
1 context sentence(design, population, supporting numbers)
For this, 5-week-old male C57BL6J mice were fed a standard (Chow) or a high-fat (HF) diet for 8 weeks. The HF diet was replaced by the chow diet for the last 2 weeks in half of HF mice, generating 3 groups: Chow, HF and HF-Chow. Vascular reactivity and western-blot assays were performed in the thoracic aorta.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).