In HUVECs, experiments using AICAR and other probes supported AMPK involvement in SAL inhibition of oxLDL-induced NADPH oxidase assembly and ROS generation.
In plain wordsIn cells, experiments using AICAR and other probes supported an AMPK mechanism for SAL antioxidant effects.
- Peptide
- AICAR (acadesine)
- Outcome
- Not applicableAMPK involvement in SAL antioxidant effects
- Study
humann: not reported in source
oxLDL-treated human umbilical vein endothelial cells- Outcome group
- Receptor activity and mechanism · Cardiovascular
Source sentences
This effect was further confirmed using knockdown AMPK with small interfering RNA (siRNA) and pharmaceutical reagents, such as the AMPK activator (AICAR), PKC inhibitor (Gö 6983), and ROS inhibitor (DPI).
2 context sentences(design, population, supporting numbers)
In addition, SAL treatment led to an inhibiting effect on the oxLDL-induced membrane assembly of NADPH oxidase subunits, and a similar effect was observed in ROS generation.
In this study, human umbilical vein endothelial cells (HUVECs) were pre-treated with SAL and oxLDL.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).