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Study · Animal study (in vivo) · rat · 2023

2 results

Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period.

Filippenkov IB, Remizova JA, Stavchansky VV, Denisova AE, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV

Genes30 Jun 2023Cited by 4 (Europe PMC)

PMID37510287 (opens in a new tab)PMCIDPMC10379992 (opens in a new tab)DOI10.3390/genes14071382 (opens in a new tab)PepBankPUB-37510287
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Summary

Ischemic stroke is an acute local decrease in cerebral blood flow due to a thrombus or embolus. Of particular importance is the study of the genetic systems that determine the mechanisms underlying the formation and maintenance of a therapeutic window (a time interval of up to 6 h after a stroke) when effective treatment can be provided. Here, we used a transient middle cerebral artery occlusion (tMCAO) model in rats to study two synthetic derivatives of adrenocorticotropic hormone (ACTH). The first was ACTH(4-7)PGP, which is known as Semax. It is actively used as a neuroprotective drug. The second was the ACTH(6-9)PGP peptide, which is elucidated as a prospective agent only. Using RNA-Seq analysis, we revealed hundreds of ischemia-related differentially expressed genes (DEGs), as well as 131 and 322 DEGs related to the first and second peptide at 4.5 h after tMCAO, respectively, in dorsolateral areas of the frontal cortex of rats. Furthermore, we showed that both Semax and ACTH(6-9)PGP can partially prevent changes in the immune- and neurosignaling-related gene expression profiles disturbed by the action of ischemia at 4.5 h after tMCAO. However, their different actions with regard to predominantly immune-related genes were also revealed. This study gives insight into how the transcriptome depends on the variation in the structure of the related peptides, and it is valuable from the standpoint of the development of measures for early post-stroke therapy.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats after tMCAO, Semax was related to 131 differentially expressed genes in the dorsolateral frontal cortex at 4.5 h.

    In plain wordsIn rats after stroke-like brain injury, Semax was linked to changes in 131 genes in the front part of the brain cortex.

    Peptide
    Semax
    Outcome
    MixedSemax-related differentially expressed genes at 4.5 h after tMCAO
    Study

    ratn: not reported in source

    transient middle cerebral artery occlusion (tMCAO) model, frontal cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Semax-related differentially expressed genes
    131 genes
    dorsolateral frontal cortex, 4.5 h after tMCAO

    Source sentences

    Summary
    Using RNA-Seq analysis, we revealed hundreds of ischemia-related differentially expressed genes (DEGs), as well as 131 and 322 DEGs related to the first and second peptide at 4.5 h after tMCAO, respectively, in dorsolateral areas of the frontal cortex of rats.
    1 context sentence
    Summary · context
    Here, we used a transient middle cerebral artery occlusion (tMCAO) model in rats to study two synthetic derivatives of adrenocorticotropic hormone (ACTH).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats after tMCAO, Semax partially prevented ischemia-induced changes in immune- and neurosignaling-related gene expression at 4.5 h.

    In plain wordsIn rats after stroke-like brain injury, Semax partly prevented changes in the activity of immune and nerve-signalling genes.

    Peptide
    Semax
    Outcome
    MixedIschemia-disturbed immune and neurosignaling gene expression
    Study

    ratn: not reported in source

    transient middle cerebral artery occlusion (tMCAO) model, frontal cortex
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we showed that both Semax and ACTH(6-9)PGP can partially prevent changes in the immune- and neurosignaling-related gene expression profiles disturbed by the action of ischemia at 4.5 h after tMCAO.
    1 context sentence
    Summary · context
    Here, we used a transient middle cerebral artery occlusion (tMCAO) model in rats to study two synthetic derivatives of adrenocorticotropic hormone (ACTH).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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