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Study · Systematic review · 2023

5 results

The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review.

Lee-Cheong S, Ludgate SA, Epp TCM, Schütz CG

Behavioural pharmacology11 Jul 2023Cited by 1 (Europe PMC)

PMID37462158 (opens in a new tab)DOI10.1097/fbp.0000000000000744 (opens in a new tab)PepBankPUB-37462158
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In people with stimulant use disorder, no included study showed a statistically significant reduction in reported cocaine use with oxytocin.

    In plain wordsIn people with stimulant use disorder, no study found that oxytocin clearly reduced cocaine use.

    Peptide
    Oxytocin
    Outcome
    No significant changeReported cocaine use
    Study

    n: not reported in source

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    no study showed a statistically significant reduction in reported cocaine use or cravings.
    1 context sentence
    Summary · context
    Six studies were included in this review, two of which were pilot studies.
  2. 02HumanSystematic reviewEfficacy outcome

    In people with stimulant use disorder, no included study showed a statistically significant reduction in cravings with oxytocin.

    In plain wordsIn people with stimulant use disorder, no study found that oxytocin clearly reduced cravings.

    Peptide
    Oxytocin
    Outcome
    No significant changeCocaine cravings
    Study

    n: not reported in source

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    no study showed a statistically significant reduction in reported cocaine use or cravings.
    1 context sentence
    Summary · context
    Six studies were included in this review, two of which were pilot studies.
  3. 03HumanSystematic reviewSafety outcome

    In people with stimulant use disorder, oxytocin was well tolerated across the included studies.

    In plain wordsIn people with stimulant use disorder, oxytocin was well tolerated across the studies reviewed.

    Peptide
    Oxytocin
    Outcome
    No significant changeTolerability
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    oxytocin was well tolerated across studies, no study showed a statistically significant reduction in reported cocaine use or cravings.
    1 context sentence
    Summary · context
    Six studies were included in this review, two of which were pilot studies.
  4. 04HumanSystematic reviewEfficacy outcome

    In one included study of people with stimulant use disorder, oxytocin increased the desire to use cocaine.

    In plain wordsIn one study of people with stimulant use disorder, oxytocin was linked to a stronger desire to use cocaine.

    Peptide
    Oxytocin
    Outcome
    IncreaseDesire to use cocaine
    Study

    n: not reported in source

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    One study suggested oxytocin increased the desire to use cocaine, although the population of participants should be taken into consideration.
    1 context sentence
    Summary · context
    Six studies were included in this review, two of which were pilot studies.
  5. 05HumanSystematic reviewEfficacy outcome

    In one included study of people with stimulant use disorder, oxytocin showed a non-significant trend towards reduced self-reported cocaine use.

    In plain wordsIn one study of people with stimulant use disorder, oxytocin showed a trend toward less cocaine use, which was not a clear effect.

    Peptide
    Oxytocin
    Outcome
    No significant changeSelf-reported cocaine use (trend)
    Study

    n: not reported in source

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, one study showed a trend towards reduced self-reported cocaine use.
    1 context sentence
    Summary · context
    Six studies were included in this review, two of which were pilot studies.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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