Skip to content

Study · Not a test of the peptide alone · 2023

2 results

Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest.

Rutledge CA, Lagranha C, Chiba T, Redding K, Stolz DB, Goetzman E, Sims-Lucas S, Kaufman BA

Journal of molecular and cellular cardiology plus5 Apr 2023Cited by 5 (Europe PMC)

PMID37425219 (opens in a new tab)PMCIDPMC10327679 (opens in a new tab)DOI10.1016/j.jmccpl.2023.100034 (opens in a new tab)PepBankPUB-37425219
Read at sourcePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In cardiac arrest mice, AICAR pretreatment outcomes supported AMPK dependence of the cardiac protection observed with metformin.

    In plain wordsIn mice with cardiac arrest, AICAR pretreatment experiments supported an AMPK mechanism for metformin-associated heart protection.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableAMPK dependence of cardiac protection
    Study

    mousen: not reported in source

    non-diabetic cardiac arrest mouse model
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    This cardiac and renal protection depends on AMPK signaling, as demonstrated by outcomes in mice pretreated with the AMPK activator AICAR or metformin plus the AMPK inhibitor compound C.
    2 context sentences
    Summary · context
    We found that two weeks of metformin pretreatment protects against reduced ejection fraction and reduces kidney ischemia-reperfusion injury at 24 h post-arrest.
    Summary · context
    The current study investigates metformin interventions on cardiac and renal outcomes in a non-diabetic CA mouse model.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In cardiac arrest mice, AICAR pretreatment outcomes supported AMPK dependence of the renal protection observed with metformin.

    In plain wordsIn mice with cardiac arrest, AICAR pretreatment experiments supported an AMPK mechanism for metformin-associated kidney protection.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableAMPK dependence of renal protection
    Study

    mousen: not reported in source

    non-diabetic cardiac arrest mouse model
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    This cardiac and renal protection depends on AMPK signaling, as demonstrated by outcomes in mice pretreated with the AMPK activator AICAR or metformin plus the AMPK inhibitor compound C.
    2 context sentences
    Summary · context
    We found that two weeks of metformin pretreatment protects against reduced ejection fraction and reduces kidney ischemia-reperfusion injury at 24 h post-arrest.
    Summary · context
    The current study investigates metformin interventions on cardiac and renal outcomes in a non-diabetic CA mouse model.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.