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Study · Randomized controlled trial · n = 52 · 2023

5 results

Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.

Vogt C, Floegel M, Kasper J, Gispert-Sánchez S, Kell CA

Social cognitive and affective neuroscience1 Jul 2023

PMID37384576 (opens in a new tab)DOI10.1093/scan/nsad035 (opens in a new tab)PepBankPUB-37384576
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin increased the second formant of produced vowels compared with placebo.

    In plain wordsIn healthy men, oxytocin changed one acoustic feature of speech compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSecond formant of produced vowels
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin administration increased the second formant of produced vowels.
    2 context sentences
    Summary · context
    During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline.
    Summary · context
    Participants were studied once under the influence of intranasal oxytocin and in another session under placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, the acoustic differences after oxytocin were not perceptually distinguishable.

    In plain wordsIn healthy men, listeners could not hear the speech differences that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceptual distinguishability of acoustic differences
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    the acoustic differences were not perceptually distinguishable in our experimental setting.
    2 context sentences
    Summary · context
    During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline.
    Summary · context
    Participants were studied once under the influence of intranasal oxytocin and in another session under placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin enhanced brain activity in sensorimotor cortices, speech processing streams, and limbic and executive control regions when preparing to speak.

    In plain wordsIn healthy men, oxytocin raised activity in speech and emotion-related brain regions when they got ready to speak, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseBrain activity when preparing to speak
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    When preparing to speak, oxytocin enhanced brain activity in sensorimotor cortices and regions of both dorsal and right ventral speech processing streams, as well as subcortical and cortical limbic and executive control regions.
    2 context sentences
    Summary · context
    During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline.
    Summary · context
    Participants were studied once under the influence of intranasal oxytocin and in another session under placebo.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, the rs53576 oxytocin receptor polymorphism modulated oxytocin-related brain activity in some regions.

    In plain wordsIn healthy men, a common oxytocin receptor gene variant changed how oxytocin affected brain activity in some regions.

    Peptide
    Oxytocin
    Outcome
    Not applicableModulation of oxytocin-related brain activity by OXTR rs53576 polymorphism
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In some of these regions, the rs53576 OXTR polymorphism modulated oxytocin administration-related brain activity.
    2 context sentences
    Summary · context
    During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline.
    Summary · context
    Participants were studied once under the influence of intranasal oxytocin and in another session under placebo.
  5. 05HumanRandomized controlled trialMechanism

    In healthy men, oxytocin gated cortical-basal ganglia circuits involved in generating happy prosody.

    In plain wordsIn healthy men, oxytocin affected brain circuits involved in speaking with a happy tone.

    Peptide
    Oxytocin
    Outcome
    Not applicableCortical-basal ganglia circuits for happy prosody
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin also gated cortical-basal ganglia circuits involved in the generation of happy prosody.
    2 context sentences
    Summary · context
    During functional magnetic resonance imaging, 52 healthy male participants read sentences out loud with either neutral or happy intonation, a covert reading condition served as a common baseline.
    Summary · context
    Participants were studied once under the influence of intranasal oxytocin and in another session under placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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