Cerebrolysin Amelioration of Spinal Cord Ischemia/ Reperfusion Injury in Rabbit Model.

Tonge C, Bektasoglu PK, Gulmez A, Turkoglu ME, Arikok AT, Erguder BI, Gurer B, Kertmen H

Turkish neurosurgery1 Jan 2023Cited by 1 (Europe PMC)

PMID37309634DOI10.5137/1019-5149.jtn.42362-22.6PepBankPUB-37309634

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rabbits with spinal cord ischemia/reperfusion injury, Cerebrolysin treatment correlated with reduced myeloperoxidase activities.
In plain wordsIn rabbits with spinal cord injury, Cerebrolysin treatment was linked to lower myeloperoxidase activities.
Peptide
Cerebrolysin
Outcome
DecreaseMyeloperoxidase activities
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all).
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963401
02AnimalAnimal study (in vivo)Mechanism
In rabbits with spinal cord ischemia/reperfusion injury, Cerebrolysin treatment correlated with reduced xanthine oxidase activities.
In plain wordsIn rabbits with spinal cord injury, Cerebrolysin treatment was linked to lower xanthine oxidase activities.
Peptide
Cerebrolysin
Outcome
DecreaseXanthine oxidase activities
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all).
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963402
03AnimalAnimal study (in vivo)Mechanism
In rabbits with spinal cord ischemia/reperfusion injury, Cerebrolysin treatment correlated with reduced malondialdehyde levels.
In plain wordsIn rabbits with spinal cord injury, Cerebrolysin treatment was linked to lower malondialdehyde levels.
Peptide
Cerebrolysin
Outcome
DecreaseMalondialdehyde levels
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all).
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963403
04AnimalAnimal study (in vivo)Mechanism
In rabbits with spinal cord ischemia/reperfusion injury, Cerebrolysin treatment correlated with reduced caspase-3 concentrations.
In plain wordsIn rabbits with spinal cord injury, Cerebrolysin treatment was linked to lower caspase-3 concentrations.
Peptide
Cerebrolysin
Outcome
DecreaseCaspase-3 concentrations
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all).
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963404
05AnimalAnimal study (in vivo)Mechanism
In rabbits with spinal cord ischemia/reperfusion injury, Cerebrolysin treatment correlated with increased catalase levels.
In plain wordsIn rabbits with spinal cord injury, Cerebrolysin treatment was linked to higher catalase levels.
Peptide
Cerebrolysin
Outcome
IncreaseCatalase levels
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all).
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963405
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with spinal cord ischemia/reperfusion injury, the Cerebrolysin group showed improved histopathological outcomes.
In plain wordsIn rabbits with spinal cord injury, the Cerebrolysin group showed improved tissue outcomes.
Peptide
Cerebrolysin
Outcome
IncreaseHistopathological outcomes
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
The cerebrolysin group showed improved histopathological, ultrastructural, and neurological outcomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963406
07AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with spinal cord ischemia/reperfusion injury, the Cerebrolysin group showed improved ultrastructural outcomes.
In plain wordsIn rabbits with spinal cord injury, the Cerebrolysin group showed improved ultrastructural outcomes.
Peptide
Cerebrolysin
Outcome
IncreaseUltrastructural outcomes
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
The cerebrolysin group showed improved histopathological, ultrastructural, and neurological outcomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963407
08AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with spinal cord ischemia/reperfusion injury, the Cerebrolysin group showed improved neurological outcomes.
In plain wordsIn rabbits with spinal cord injury, the Cerebrolysin group showed improved neurological outcomes.
Peptide
Cerebrolysin
Outcome
IncreaseNeurological outcomes
Study
rabbitn: not reported in source
spinal cord ischemia/reperfusion injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 ml/kgAs given in this study (rabbit).
Source sentences
Summary
The cerebrolysin group showed improved histopathological, ultrastructural, and neurological outcomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group.
Report a problemFND-3730963408

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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