Assessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly.

Teramoto S, Tahara S, Hattori Y, Kondo A, Morita A

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2 Jun 2023

PMID37295337DOI10.1016/j.ghir.2023.101545PepBankPUB-37295337

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. 1 result from people.

01HumanObservational studyOther
In elderly patients with non-functioning PitNET, ROC analysis found an optimal peak GH cut-off of 8.08 ng/mL in the GHRP‑2 test for linking with adrenocortical function.
In plain wordsIn older patients with a pituitary tumor, a peak growth hormone of 8.08 ng/mL in a GHRP‑2 test best matched adrenal function.
Peptide
GHRP-2
Outcome
Not applicableOptimal cut-off of peak GH in the GHRP-2 test for adrenocortical function
Study
n = 65
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Optimal peak GH cut-off
8.08 ng/mL
GHRP-2 test
Specificity
0.868
GHRP-2 test cut-off
Sensitivity
0.852
GHRP-2 test cut-off
Source sentences
Summary
In addition, receiver operating characteristic curve analysis identified that the optimal cut-off point for a peak GH level in the correlation between adrenocortical function and GH response to the GHRP-2 test was 8.08 ng/mL (specificity 0.868, sensitivity 0.852).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test.
Report a problemFND-3729533705

Studies that did not test the peptide alone4

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

02HumanNot a test of GHRP-2 aloneObservational studyOther
In elderly patients with non-functioning PitNET, cortisol in the CRH test was higher in the group with a normal GH response to the GHRP‑2 test than in the GH deficiency group.
In plain wordsIn older patients with a pituitary tumor, cortisol after a CRH test was higher in those with a normal GHRP‑2 growth hormone response.
Peptide
GHRP-2
Outcome
IncreaseCortisol result in the CRH test, GH normal versus GH deficiency group
Study
n = 65
Comparator
GH deficiency group
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The cortisol and adrenocorticotropic hormone (ACTH) results in the corticotropin-releasing hormone test were significantly higher in the GH normal group than in the GH deficiency group (p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3729533701
03HumanNot a test of GHRP-2 aloneObservational studyOther
In elderly patients with non-functioning PitNET, ACTH in the CRH test was higher in the group with a normal GH response to the GHRP‑2 test than in the GH deficiency group.
In plain wordsIn older patients with a pituitary tumor, ACTH after a CRH test was higher in those with a normal GHRP‑2 growth hormone response.
Peptide
GHRP-2
Outcome
IncreaseACTH result in the CRH test, GH normal versus GH deficiency group
Study
n = 65
Comparator
GH deficiency group
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The cortisol and adrenocorticotropic hormone (ACTH) results in the corticotropin-releasing hormone test were significantly higher in the GH normal group than in the GH deficiency group (p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3729533702
04HumanNot a test of GHRP-2 aloneObservational studyOther
In elderly patients with non-functioning PitNET, cortisol results correlated significantly with the GH response to the GHRP‑2 test.
In plain wordsIn older patients with a pituitary tumor, cortisol results were linked to the growth hormone response in a GHRP‑2 test.
Peptide
GHRP-2
Outcome
Not applicableCorrelation of CRH-test cortisol with GH response to the GHRP-2 test
Study
n = 65
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The relationship between the cortisol and ACTH results and the GH response revealed significant correlations (p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3729533703
05HumanNot a test of GHRP-2 aloneObservational studyOther
In elderly patients with non-functioning PitNET, ACTH results correlated significantly with the GH response to the GHRP‑2 test.
In plain wordsIn older patients with a pituitary tumor, ACTH results were linked to the growth hormone response in a GHRP‑2 test.
Peptide
GHRP-2
Outcome
Not applicableCorrelation of CRH-test ACTH with GH response to the GHRP-2 test
Study
n = 65
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The relationship between the cortisol and ACTH results and the GH response revealed significant correlations (p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty-five elderly patients aged 65 years and older with non-functioning pituitary neuroendocrine tumor (PitNET) who underwent pituitary surgery and preoperative endocrine stimulation tests were classified into the "GH normal group" and "GH deficiency group" based on GH response to the GHRP-2 test.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3729533704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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