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Study · Animal study (in vivo) · mouse · 2023

15 results

Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway.

Jiang J, Xu L, Yang L, Liu S, Wang Z

ACS chemical neuroscience7 Jun 2023Cited by 20 (Europe PMC)

PMID37285113 (opens in a new tab)DOI10.1021/acschemneuro.3c00140 (opens in a new tab)PepBankPUB-37285113
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spared nerve injury, MOTS‑c produced pronounced dose-dependent antinociceptive effects.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c reduced pain-like responses, with stronger effects at higher doses.

    Peptide
    MOTS-c
    Outcome
    DecreaseAntinociceptive effect
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment produced pronounced dose-dependent antinociceptive effects in SNI mice
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, the AMPK inhibitor dorsomorphin blocked the antinociceptive effects of MOTS‑c.

    In plain wordsIn mice with nerve-injury pain, blocking AMPK with dorsomorphin removed the pain-relieving effect of MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    No significant changeAntinociception with the AMPK inhibitor dorsomorphin
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    MOTS-c without dorsomorphin
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    these effects were blocked by dorsomorphin, an AMPK inhibitor
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, the antinociceptive effects of MOTS‑c were not blocked by the opioid receptor antagonist naloxone.

    In plain wordsIn mice with nerve-injury pain, the opioid blocker naloxone did not stop the pain-relieving effect of MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    DecreaseAntinociception with the opioid antagonist naloxone
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    MOTS-c without naloxone
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but not naloxone, a nonselective opioid receptor antagonist.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, intrathecal MOTS‑c significantly increased AMPKα1/2 phosphorylation in the lumbar spinal cord.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c injected into the spinal canal raised AMPK activation in the lower spinal cord.

    Peptide
    MOTS-c
    Outcome
    IncreaseLumbar spinal cord AMPKα1/2 phosphorylation
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, intrathecal (i.t.) injection of MOTS-c significantly enhanced AMPKα1/2 phosphorylation in the lumbar spinal cord of SNI mice.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, MOTS‑c significantly inhibited proinflammatory cytokine production in the spinal cord.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c reduced inflammatory signal protein production in the spinal cord.

    Peptide
    MOTS-c
    Outcome
    DecreaseSpinal cord proinflammatory cytokine production
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c also significantly inhibited proinflammatory cytokine production and microglia activation in the spinal cord.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, MOTS‑c significantly inhibited microglia activation in the spinal cord.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c reduced the activation of microglia, immune cells of the spinal cord.

    Peptide
    MOTS-c
    Outcome
    DecreaseSpinal cord microglia activation
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c also significantly inhibited proinflammatory cytokine production and microglia activation in the spinal cord.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, the antinociceptive effects of MOTS‑c were retained when spinal microglia were inhibited by minocycline.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c still relieved pain-like responses when microglia were blocked with minocycline.

    Peptide
    MOTS-c
    Outcome
    DecreaseAntinociception after minocycline inhibition of microglia
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    MOTS-c without minocycline
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antinociceptive effects of MOTS-c were retained even when microglia activation in the spinal cord was inhibited by minocycline pretreatment, indicating that spinal cord microglia are dispensable for the antiallodynic effects of MOTS-c.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, MOTS‑c treatment inhibited c-Fos expression in the spinal dorsal horn, mainly in neurons rather than microglia.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c lowered c-Fos, a nerve activity marker, in spinal cord neurons.

    Peptide
    MOTS-c
    Outcome
    Decreasec-Fos expression in spinal dorsal horn neurons
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the spinal dorsal horn, MOTS-c treatment inhibited c-Fos expression and oxidative damage mainly in neurons rather than microglia.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with spared nerve injury, MOTS‑c treatment inhibited oxidative damage in the spinal dorsal horn, mainly in neurons rather than microglia.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c reduced oxidative damage in spinal cord neurons.

    Peptide
    MOTS-c
    Outcome
    DecreaseOxidative damage in spinal dorsal horn neurons
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the spinal dorsal horn, MOTS-c treatment inhibited c-Fos expression and oxidative damage mainly in neurons rather than microglia.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  10. 10AnimalAnimal study (in vivo)Safety outcome

    In mice with spared nerve injury, intrathecal MOTS‑c caused limited side effects relating to antinociceptive tolerance, in contrast to morphine.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c injected into the spinal canal caused less pain-relief tolerance than morphine.

    Peptide
    MOTS-c
    Outcome
    DecreaseAntinociceptive tolerance versus morphine
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Morphine
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Finally, in contrast to morphine, i.t. administration of MOTS-c resulted in limited side effects relating to antinociceptive tolerance, gastrointestinal transit inhibition, locomotor function, and motor coordination.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  11. 11AnimalAnimal study (in vivo)Safety outcome

    In mice with spared nerve injury, intrathecal MOTS‑c caused limited gastrointestinal transit inhibition, in contrast to morphine.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c injected into the spinal canal slowed gut movement less than morphine.

    Peptide
    MOTS-c
    Outcome
    DecreaseGastrointestinal transit inhibition versus morphine
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Morphine
    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Finally, in contrast to morphine, i.t. administration of MOTS-c resulted in limited side effects relating to antinociceptive tolerance, gastrointestinal transit inhibition, locomotor function, and motor coordination.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  12. 12AnimalAnimal study (in vivo)Safety outcome

    In mice with spared nerve injury, intrathecal MOTS‑c caused limited side effects on locomotor function, in contrast to morphine.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c injected into the spinal canal affected movement less than morphine.

    Peptide
    MOTS-c
    Outcome
    DecreaseLocomotor function versus morphine
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Morphine
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Finally, in contrast to morphine, i.t. administration of MOTS-c resulted in limited side effects relating to antinociceptive tolerance, gastrointestinal transit inhibition, locomotor function, and motor coordination.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.
  13. 13AnimalAnimal study (in vivo)Safety outcome

    In mice with spared nerve injury, intrathecal MOTS‑c caused limited side effects on motor coordination, in contrast to morphine.

    In plain wordsIn mice with nerve-injury pain, MOTS‑c injected into the spinal canal affected coordination less than morphine.

    Peptide
    MOTS-c
    Outcome
    DecreaseMotor coordination versus morphine
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Morphine
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Finally, in contrast to morphine, i.t. administration of MOTS-c resulted in limited side effects relating to antinociceptive tolerance, gastrointestinal transit inhibition, locomotor function, and motor coordination.
    1 context sentence
    Summary · context
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 14AnimalEndogenous levelAnimal study (in vivo)Other

    Plasma levels of the body's own MOTS‑c were significantly lower in mice with spared nerve injury neuropathic pain than in control animals.

    In plain wordsIn mice with nerve-injury pain, the body's own MOTS‑c in blood was lower than in control mice.

    Peptide
    MOTS-c
    Outcome
    DecreasePlasma MOTS-c level in SNI mice
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Control animals
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 15AnimalEndogenous levelAnimal study (in vivo)Other

    Levels of the body's own MOTS‑c in the spinal dorsal horn were significantly lower in mice with spared nerve injury neuropathic pain than in control animals.

    In plain wordsIn mice with nerve-injury pain, the body's own MOTS‑c in the spinal cord was lower than in control mice.

    Peptide
    MOTS-c
    Outcome
    DecreaseSpinal dorsal horn MOTS-c level in SNI mice
    Study

    mousen: not reported in source

    Spared nerve injury (SNI) neuropathic pain
    Comparator
    Control animals
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    We found that MOTS-c levels in plasma and spinal dorsal horn were significantly lower in mice with spared nerve injury (SNI)-induced neuropathic pain than in control animals.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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