In children with autism spectrum disorder, repeated oxytocin dampened the increase in neural sensitivity to expressive faces that occurred in the placebo group.
In plain wordsIn children with autism, repeated oxytocin reduced a rise in brain response to faces that happened with placebo, which fits a learning effect.
- Peptide
- Oxytocin
- Outcome
- DecreaseLearning-related increase in neural sensitivity to expressive faces, oxytocin versus placebo
- Study
n = 61
- Comparator
- Placebo
- Analysis
- Exploratory
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- 12 IU twice daily · intranasal · 4 weeksAs given in this study (human).
Source sentences
children with ASD displayed a significant increase in neural sensitivity at the post- and follow-up sessions, but only in the placebo group
3 context sentences(design, population, supporting numbers)
Strikingly, in the OT group, neural sensitivity remained unaffected from the baseline to the post-session, likely reflecting a dampening of an otherwise typically occurring implicit learning effect.
repeated OT administration dampened typically occurring learning effects in neural sensitivity.
In this randomized, double-blind, placebo-controlled, mechanistic pharmaco-neuroimaging clinical trial, we implemented frequency-tagging EEG to conduct an exploratory investigation into the impact of repeated OT administration (4 weeks, 12 IU, twice daily) on neural sensitivity towards happy and fea…