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Study · Animal study (in vivo) · mouse · 2023

8 results

Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cells.

Zhang Q, Liu J, Deng MM, Tong R, Hou G

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie29 May 2023Cited by 7 (Europe PMC)

PMID37257226 (opens in a new tab)DOI10.1016/j.biopha.2023.114936 (opens in a new tab)PepBankPUB-37257226
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovalbumin-induced asthmatic mice, GHK‑Cu administration decreased peribronchial collagen deposition compared with PBS.

    In plain wordsIn mice with asthma, GHK‑Cu reduced collagen build-up around the airways compared with PBS.

    Peptide
    GHK-Cu
    Outcome
    DecreasePeribronchial collagen deposition
    Study

    mousen: not reported in source

    Ovalbumin-induced asthma model
    Comparator
    PBS
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu administration alleviated airway remodeling, as reflected by decreased peribronchial collagen deposition and airway mucus secretion, and suppressed epithelial-mesenchymal transition.
    1 context sentence
    Summary · context
    Ovalbumin-induced mice of asthma model treated with PBS or GHK-Cu (a form of GHK with higher bioavailability) were used to evaluate the effect of exogenous GHK supplement on airway remodeling.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovalbumin-induced asthmatic mice, GHK‑Cu administration decreased airway mucus secretion compared with PBS.

    In plain wordsIn mice with asthma, GHK‑Cu reduced mucus in the airways compared with PBS.

    Peptide
    GHK-Cu
    Outcome
    DecreaseAirway mucus secretion
    Study

    mousen: not reported in source

    Ovalbumin-induced asthma model
    Comparator
    PBS
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu administration alleviated airway remodeling, as reflected by decreased peribronchial collagen deposition and airway mucus secretion, and suppressed epithelial-mesenchymal transition.
    1 context sentence
    Summary · context
    Ovalbumin-induced mice of asthma model treated with PBS or GHK-Cu (a form of GHK with higher bioavailability) were used to evaluate the effect of exogenous GHK supplement on airway remodeling.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovalbumin-induced asthmatic mice, GHK‑Cu suppressed epithelial-mesenchymal transition.

    In plain wordsIn mice with asthma, GHK‑Cu limited a cell change linked to airway scarring compared with PBS.

    Peptide
    GHK-Cu
    Outcome
    DecreaseEpithelial-mesenchymal transition
    Study

    mousen: not reported in source

    Ovalbumin-induced asthma model
    Comparator
    PBS
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    suppressed epithelial-mesenchymal transition.
    1 context sentence
    Summary · context
    Ovalbumin-induced mice of asthma model treated with PBS or GHK-Cu (a form of GHK with higher bioavailability) were used to evaluate the effect of exogenous GHK supplement on airway remodeling.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In ovalbumin-induced asthmatic mice, the therapeutic effect of GHK‑Cu was related to a decreased TGF-β1 level.

    In plain wordsIn mice with asthma, the benefit of GHK‑Cu was linked to a lower level of TGF-β1.

    Peptide
    GHK-Cu
    Outcome
    DecreaseTGF-β1 level
    Study

    mousen: not reported in source

    Ovalbumin-induced asthma model
    Comparator
    PBS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The therapeutical effect related to decreased TGF-β1 level.
    1 context sentence
    Summary · context
    Ovalbumin-induced mice of asthma model treated with PBS or GHK-Cu (a form of GHK with higher bioavailability) were used to evaluate the effect of exogenous GHK supplement on airway remodeling.
  5. 05LabIn vitro (cells)Mechanism

    In airway epithelial cells, GHK‑Cu increased SIRT1 expression and activated SIRT1 deacetylation, which decreased TGF-β1 level.

    In plain wordsIn cells from the airway lining, GHK‑Cu raised SIRT1 activity, which was linked to lower TGF-β1.

    Peptide
    GHK-Cu
    Outcome
    IncreaseSIRT1 expression and deacetylation activity
    Study

    n: not reported in source

    Airway epithelial cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu decreased TGF-β1 level by increasing SIRT1 expression and activating SIRT1 deacetylation in airway epithelial cells

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 06HumanEndogenous levelObservational studyOther

    Plasma GHK levels were significantly lower in patients with asthma than in age-matched healthy controls.

    In plain wordsPatients with asthma had lower levels of the body's own GHK in blood than healthy people of the same age.

    Peptide
    GHK-Cu
    Outcome
    DecreasePlasma GHK level in asthma
    Study

    n: not reported in source

    Comparator
    Age-matched healthy controls
    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    Our result showed that the plasma GHK levels of patients with asthma were significantly lower than those of age-matched healthy controls.

    This result measures the body's own GHK-Cu. Nobody was given the peptide. It is not evidence about taking it.

  2. 07HumanEndogenous levelObservational studyOther

    In asthma patients, those with fixed airflow limitation had significantly lower plasma GHK levels.

    In plain wordsAsthma patients with fixed airflow limitation had lower levels of the body's own GHK in blood.

    Peptide
    GHK-Cu
    Outcome
    DecreasePlasma GHK level in asthma with fixed airflow limitation
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    patients with FAO had significantly lower GHK levels.

    This result measures the body's own GHK-Cu. Nobody was given the peptide. It is not evidence about taking it.

  3. 08HumanEndogenous levelObservational studyOther

    In asthma patients, plasma GHK levels showed a moderate correlation with FEF25-75%.

    In plain wordsIn asthma patients, the body's own GHK level in blood was linked to a measure of small airway flow.

    Peptide
    GHK-Cu
    Outcome
    Not applicableCorrelation of plasma GHK with FEF25-75%
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    In asthma patients, plasma GHK levels display a moderate correlation with FEF25-75%

    This result measures the body's own GHK-Cu. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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