Skip to content

Study · Measured the body's own peptide · 2023

1 result

Β-GPA administration activates slow oxidative muscle signaling pathways and protects soleus muscle against the increased fatigue under 7-days of rat hindlimb suspension.

Sharlo KA, Lvova ID, Sidorenko DA, Tyganov SA, Sharlo DT, Shenkman BS

Archives of biochemistry and biophysics24 May 2023Cited by 6 (Europe PMC)

PMID37230367 (opens in a new tab)DOI10.1016/j.abb.2023.109647 (opens in a new tab)PepBankPUB-37230367
Publisher pagePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats with 7-day hindlimb suspension, β-GPA treatment protected the slow-type signaling network, including the muscle's own MOTS‑C, in the unloaded soleus.

    In plain wordsIn rats with unloaded leg muscles, β-GPA protected the muscle's own MOTS‑C signaling.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedMOTS-C signaling in unloaded soleus with β-GPA
    Study

    ratn: not reported in source

    7-day hindlimb suspension, soleus muscle
    Comparator
    7-day hindlimb suspension without β-GPA
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    In the 7HB group, β-GPA treatment protected a slow-type signaling network in an unloaded soleus muscle, including MOTS-C, AMPK, PGC1 α and micro-RNA-499.
    1 context sentence
    Summary · context
    Male Wistar rats were divided into 3 groups (n = 8): C - vivarium control; 7HS - 7-day hindlimb suspension; 7HB - 7-day hindlimb suspension with intraperitoneal injection of beta-guanidine propionic acid (β-GPA, 400 mg/kg b w).

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.