Fucoidan (A Sulfated Polysaccharide) and Cerebroprotein in Combination Alleviate the Neuroinflammation-mediated Neural Damage and Functional Deficits in the Focal Cerebral Ischemia Model of Rat.

Nambi P, Sathyamoorthy Y, Kaliyappan K, Radhakrishnan R

Neuroscience13 May 2023Cited by 7 (Europe PMC)

PMID37182836DOI10.1016/j.neuroscience.2023.05.003PepBankPUB-37182836

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study21

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, Cerebrolysin alone improved neurobehavioral assessments.
In plain wordsIn rats with cerebral ischemia, Cerebrolysin alone improved behavioral assessments.
Peptide
Cerebrolysin
Outcome
IncreaseNeurobehavioral assessments
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 mg/kg body weightAs given in this study (rat).
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments
Report a problemFND-3718283601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, Cerebrolysin alone improved histopathological assessments.
In plain wordsIn rats with cerebral ischemia, Cerebrolysin alone improved tissue assessments.
Peptide
Cerebrolysin
Outcome
IncreaseHistopathological assessments
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 mg/kg body weightAs given in this study (rat).
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments
Report a problemFND-3718283602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin reduced neurological deficits versus Fucoidan alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced neurological deficits compared with Fucoidan alone.
Peptide
Cerebrolysin
Outcome
DecreaseNeurological deficits
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Fucoidan alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments and the combination has made a significant reduction in the neurological deficits and the infarct volume when compared to the standalone groups.
Report a problemFND-3718283603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin reduced infarct volume versus Fucoidan alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced infarct volume compared with Fucoidan alone.
Peptide
Cerebrolysin
Outcome
DecreaseInfarct volume
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Fucoidan alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments and the combination has made a significant reduction in the neurological deficits and the infarct volume when compared to the standalone groups.
Report a problemFND-3718283605
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin preserved blood-brain barrier integrity versus Fucoidan alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin preserved the brain barrier compared with Fucoidan alone.
Peptide
Cerebrolysin
Outcome
IncreaseBlood-brain barrier integrity
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Fucoidan alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The BBB integrity was well preserved in the combination group when compared with the lesion and standalone groups.
Report a problemFND-3718283608

Studies that did not test the peptide alone16

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin reduced neurological deficits versus Cerebrolysin alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced neurological deficits compared with Cerebrolysin alone.
Peptide
Cerebrolysin
Outcome
DecreaseNeurological deficits
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Cerebrolysin alone
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments and the combination has made a significant reduction in the neurological deficits and the infarct volume when compared to the standalone groups.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283604
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin reduced infarct volume versus Cerebrolysin alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced infarct volume compared with Cerebrolysin alone.
Peptide
Cerebrolysin
Outcome
DecreaseInfarct volume
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Cerebrolysin alone
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The stand-alone treatment with Fucoidan, Cerebrolysin has shown a better outcome in the neurobehavioral and, histopathological assessments and the combination has made a significant reduction in the neurological deficits and the infarct volume when compared to the standalone groups.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283606
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin preserved blood-brain barrier integrity versus the lesion group.
In plain wordsIn rats, Fucoidan plus Cerebrolysin preserved the brain barrier compared with the lesion group.
Peptide
Cerebrolysin
Outcome
IncreaseBlood-brain barrier integrity
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Lesion group
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The BBB integrity was well preserved in the combination group when compared with the lesion and standalone groups.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283607
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats, Fucoidan plus Cerebrolysin preserved blood-brain barrier integrity versus Cerebrolysin alone.
In plain wordsIn rats, Fucoidan plus Cerebrolysin preserved the brain barrier compared with Cerebrolysin alone.
Peptide
Cerebrolysin
Outcome
IncreaseBlood-brain barrier integrity
Study
ratn: not reported in source
right middle cerebral artery occlusion
Comparator
Cerebrolysin alone
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The BBB integrity was well preserved in the combination group when compared with the lesion and standalone groups.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283609
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced TNFα levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced TNFα levels.
Peptide
Cerebrolysin
Outcome
DecreaseTNFα level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283610
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced NFkB levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced NFkB levels.
Peptide
Cerebrolysin
Outcome
DecreaseNFkB level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283611
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL1α levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL1α levels.
Peptide
Cerebrolysin
Outcome
DecreaseIL1α level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283612
13AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL1-β levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL1-β levels.
Peptide
Cerebrolysin
Outcome
DecreaseIL1-β level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283613
14AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL-6 levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL-6 levels.
Peptide
Cerebrolysin
Outcome
DecreaseIL-6 level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283614
15AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced CD68 levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced CD68 levels.
Peptide
Cerebrolysin
Outcome
DecreaseCD68 level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283615
16AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced COX-2 levels.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced COX-2 levels.
Peptide
Cerebrolysin
Outcome
DecreaseCOX-2 level
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283616
17AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL1α mRNA expression.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL1α gene expression.
Peptide
Cerebrolysin
Outcome
DecreaseIL1α mRNA expression
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283617
18AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL1-β mRNA expression.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL1-β gene expression.
Peptide
Cerebrolysin
Outcome
DecreaseIL1-β mRNA expression
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283618
19AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IL-6 mRNA expression.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IL-6 gene expression.
Peptide
Cerebrolysin
Outcome
DecreaseIL-6 mRNA expression
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283619
20AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced IBA-1 mRNA expression.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced IBA-1 gene expression.
Peptide
Cerebrolysin
Outcome
DecreaseIBA-1 mRNA expression
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283620
21AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats, Fucoidan plus Cerebrolysin reduced COX-2 mRNA expression.
In plain wordsIn rats, Fucoidan plus Cerebrolysin reduced COX-2 gene expression.
Peptide
Cerebrolysin
Outcome
DecreaseCOX-2 mRNA expression
Study
ratn: not reported in source
right middle cerebral artery occlusion
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
Moreover, the combined intervention reduced the level of pro-inflammatory cytokines TNFα, NFkB, IL1α, IL1-β, IL-6, CD68, COX-2, and mRNA expression of inflammatory genes IL1α, IL1-β, IL-6, IBA-1, and COX-2 effectively.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3718283621

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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