The Effect of Drugs with α-Glutamyl-Tryptophan for Cytokine Secretion and Level of Surface Molecule ICAM-1 In Vitro.

Golovacheva EG, Starikova EA, Kudryavtseva TA, Apryatina VA

Cell and tissue biology27 Apr 2023Cited by 1 (Europe PMC)

PMID37131521PMCIDPMC10134718DOI10.1134/s1990519x23020050PepBankPUB-37131521

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In endothelial cells, α-Glu-Trp reduced TNFα-induced IL-1α production.
In plain wordsIn cells, α-Glu-Trp reduced TNFα-induced IL-1α production.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseTNFα-induced IL-1α production
Study
humann: not reported in source
EA.hy 926 endothelial cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
It was shown that α-Glu-Trp reduced TNFα-induced IL-1α production and increased TNFα-stimulated level of the ICAM-1 surface molecule of endothelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
Report a problemFND-3713152101
02LabIn vitro (cells)Mechanism
In endothelial cells, α-Glu-Trp increased TNFα-stimulated surface ICAM-1 levels.
In plain wordsIn cells, α-Glu-Trp increased TNFα-stimulated surface ICAM-1 levels.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseTNFα-stimulated surface ICAM-1
Study
humann: not reported in source
EA.hy 926 endothelial cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
It was shown that α-Glu-Trp reduced TNFα-induced IL-1α production and increased TNFα-stimulated level of the ICAM-1 surface molecule of endothelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
Report a problemFND-3713152102
03LabIn vitro (cells)Mechanism
In mononuclear cells, α-Glu-Trp reduced TNFα-induced IL-8 secretion.
In plain wordsIn cells, α-Glu-Trp reduced TNFα-induced IL-8 release.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseTNFα-induced IL-8 secretion
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
At the same time, the drug reduced secretion of the IL-8 cytokine induced by TNFα and increased the spontaneous level of ICAM-1 in mononuclear cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
Report a problemFND-3713152103
04LabIn vitro (cells)Mechanism
In mononuclear cells, α-Glu-Trp increased spontaneous ICAM-1 levels.
In plain wordsIn cells, α-Glu-Trp increased spontaneous ICAM-1 levels.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseSpontaneous ICAM-1 level
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
At the same time, the drug reduced secretion of the IL-8 cytokine induced by TNFα and increased the spontaneous level of ICAM-1 in mononuclear cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
Report a problemFND-3713152104

Studies that did not test the peptide alone4

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

05LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In endothelial cells, Cytovir-3 containing α-Glu-Trp increased spontaneous IL-8 secretion.
In plain wordsIn cells, Cytovir-3 containing α-Glu-Trp increased spontaneous IL-8 release.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseSpontaneous IL-8 secretion
Study
humann: not reported in source
EA.hy 926 endothelial cells
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In its presence, there was an increase in the spontaneous secretion of IL-8 by endothelial and mononuclear cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Cytovir-3 had an activating effect on EA.hy 926 endothelial cells and human peripheral blood mononuclear leukocytes.
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3713152105
06LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In mononuclear cells, Cytovir-3 containing α-Glu-Trp increased spontaneous IL-8 secretion.
In plain wordsIn cells, Cytovir-3 containing α-Glu-Trp increased spontaneous IL-8 release.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseSpontaneous IL-8 secretion
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In its presence, there was an increase in the spontaneous secretion of IL-8 by endothelial and mononuclear cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Cytovir-3 had an activating effect on EA.hy 926 endothelial cells and human peripheral blood mononuclear leukocytes.
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3713152106
07LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In endothelial cells, Cytovir-3 containing α-Glu-Trp increased TNFα-induced ICAM-1 levels.
In plain wordsIn cells, Cytovir-3 containing α-Glu-Trp increased TNFα-induced ICAM-1 levels.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseTNFα-induced ICAM-1
Study
humann: not reported in source
EA.hy 926 endothelial cells
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In addition, Cytovir-3 increased the level of TNFα-induced ICAM-1 on endothelial cells and increased the spontaneous level of this surface molecule on mononuclear cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3713152107
08LabNot a test of Thymogen (oglufanide) aloneIn vitro (cells)Mechanism
In mononuclear cells, Cytovir-3 containing α-Glu-Trp increased spontaneous ICAM-1 levels.
In plain wordsIn cells, Cytovir-3 containing α-Glu-Trp increased spontaneous ICAM-1 levels.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseSpontaneous ICAM-1
Study
humann: not reported in source
Peripheral blood mononuclear cells
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In addition, Cytovir-3 increased the level of TNFα-induced ICAM-1 on endothelial cells and increased the spontaneous level of this surface molecule on mononuclear cells.
1 context sentence(design, population, supporting numbers)
Summary · context
in EA.hy 926 endothelial cell culture and peripheral blood mononuclear cells of healthy donors, is studied using an in vitro model of inflammation in the presence of α-glutamyl-tryptophan (α-Glu-Trp) and Cytovir-3.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3713152108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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