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Study · Animal study (in vivo) · mouse · 2023

4 results

FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.

Liu Y, Hou Q, Wang R, Liu Y, Cheng Z

Naunyn-Schmiedeberg's archives of pharmacology19 Apr 2023Cited by 8 (Europe PMC)

PMID37074394 (opens in a new tab)DOI10.1007/s00210-023-02452-2 (opens in a new tab)PepBankPUB-37074394
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-induced pulmonary fibrosis in mice, therapeutic FOXO4‑DRI gave milder pathologic change than the bleomycin-only group.

    In plain wordsIn mice with lung scarring, FOXO4‑DRI treatment gave milder lung damage than no treatment.

    Peptide
    FOXO4-DRI
    Outcome
    DecreasePathologic change in the lung
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    BLM-induced group
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The animal group of FOXO4-DRI therapeutic administration shows a milder pathologic change and less collagen deposition compared with the BLM-induced group.
    1 context sentence
    Summary · context
    In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-induced pulmonary fibrosis in mice, therapeutic FOXO4‑DRI gave less collagen deposition than the bleomycin-only group.

    In plain wordsIn mice with lung scarring, FOXO4‑DRI treatment gave less collagen buildup than no treatment.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseCollagen deposition
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    BLM-induced group
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The animal group of FOXO4-DRI therapeutic administration shows a milder pathologic change and less collagen deposition compared with the BLM-induced group.
    1 context sentence
    Summary · context
    In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts model.
  3. 03LabIn vitro (cells)Mechanism

    FOXO4‑DRI reset the distribution of intranuclear p53.

    In plain wordsIn this study, FOXO4‑DRI changed where p53 sits inside the cell nucleus.

    Peptide
    FOXO4-DRI
    Outcome
    Not applicableIntranuclear p53 distribution
    Study

    n: not reported in source

    Activated fibroblasts model or BLM mouse model (not specified in this sentence)
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found the FOXO4-DRI resets the distribution of intranuclear p53 and concurrently decreased the total ECM proteins content.
    1 context sentence
    Summary · context
    In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts model.
  4. 04LabIn vitro (cells)Efficacy outcome

    FOXO4‑DRI decreased the total extracellular matrix protein content.

    In plain wordsIn this study, FOXO4‑DRI reduced the total amount of scar-tissue proteins.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseTotal ECM protein content
    Study

    n: not reported in source

    Activated fibroblasts model or BLM mouse model (not specified in this sentence)
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found the FOXO4-DRI resets the distribution of intranuclear p53 and concurrently decreased the total ECM proteins content.
    1 context sentence
    Summary · context
    In this research, we explored the effect of FOXO4-DRI on bleomycin (BLM)-induced PF mouse model and activated fibroblasts model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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