Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins.

Bahar MR, Tekin S, Beytur A, Onalan EE, Ozyalin F, Colak C, Sandal S

Biologia futura17 Apr 2023Cited by 2 (Europe PMC)

PMID37067760DOI10.1007/s42977-023-00163-6PepBankPUB-37067760

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular MOTS‑c infusion increased food consumption.
In plain wordsIn rats, MOTS‑c infused into the brain increased how much the rats ate.
Peptide
MOTS-c
Outcome
IncreaseFood consumption
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion was found to increase food consumption
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776001
02AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular MOTS‑c infusion did not change body weight.
In plain wordsIn rats, MOTS‑c infused into the brain did not change body weight.
Peptide
MOTS-c
Outcome
No significant changeBody weight
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Body weight · Metabolic and weight
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
it did not cause any changes in the body weight.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776002
03AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular MOTS‑c infusion decreased serum TSH.
In plain wordsIn rats, MOTS‑c infused into the brain lowered blood thyroid-stimulating hormone.
Peptide
MOTS-c
Outcome
DecreaseSerum TSH
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
MOTS-c decreased serum TSH, T3, and T4 hormone levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776003
04AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular MOTS‑c infusion decreased serum T3.
In plain wordsIn rats, MOTS‑c infused into the brain lowered blood T3 thyroid hormone.
Peptide
MOTS-c
Outcome
DecreaseSerum T3
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
MOTS-c decreased serum TSH, T3, and T4 hormone levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776004
05AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular MOTS‑c infusion decreased serum T4.
In plain wordsIn rats, MOTS‑c infused into the brain lowered blood T4 thyroid hormone.
Peptide
MOTS-c
Outcome
DecreaseSerum T4
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
MOTS-c decreased serum TSH, T3, and T4 hormone levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776005
06AnimalAnimal study (in vivo)Mechanism
In male rats, intracerebroventricular MOTS‑c infusion increased UCP1 levels in peripheral tissues.
In plain wordsIn rats, MOTS‑c infused into the brain raised UCP1 levels in tissues outside the brain.
Peptide
MOTS-c
Outcome
IncreaseUCP1 level in peripheral tissues
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776006
07AnimalAnimal study (in vivo)Mechanism
In male rats, intracerebroventricular MOTS‑c infusion increased UCP3 levels in peripheral tissues.
In plain wordsIn rats, MOTS‑c infused into the brain raised UCP3 levels in tissues outside the brain.
Peptide
MOTS-c
Outcome
IncreaseUCP3 level in peripheral tissues
Study
ratn = 40
Male Wistar Albino rats
Comparator
Control and sham groups
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
10 and 100 µM · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c.
Report a problemFND-3706776007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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