Skip to content

Study · Not a test of the peptide alone · 2023

3 results

EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.

Lezhava T, Jokhadze T, Monaselidze J, Buadze T, Gaiozishvili M, Sigua T, Khujadze I, Gogidze K, Mikaia N, Chigvinadze N

Georgian medical news1 Feb 2023Cited by 1 (Europe PMC)

PMID37042594 (opens in a new tab)PepBankPUB-37042594
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

  1. 01LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In cultured lymphocytes from old individuals, a pool of four peptide bioregulators including Epitalon induced decondensation of total heterochromatin.

    In plain wordsIn lab-grown lymphocytes from older donors, a group of four short peptides, including Epitalon, loosened condensed chromatin.

    Peptide
    Epitalon
    Outcome
    DecreaseTotal heterochromatin condensation
    Study

    humann: not reported in source

    Cultured lymphocytes from 75-88-year-old individuals
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    We show that peptide bioregulators induced unrolling deheterochromatinization (decondensation) of total heterochromatin
    1 context sentence
    Summary · context
    the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin in lymphocytes from old individuals

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 02LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In cultured lymphocytes from old individuals, a pool of four peptide bioregulators including Epitalon deheterochromatinized satellite stalks of acrocentric chromosomes and activated ribosomal genes.

    In plain wordsIn lab-grown lymphocytes from older donors, a group of four short peptides, including Epitalon, activated ribosomal genes.

    Peptide
    Epitalon
    Outcome
    IncreaseRibosomal gene activity at satellite stalks
    Study

    humann: not reported in source

    Cultured lymphocytes from 75-88-year-old individuals
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    deheterochromatinization of satellite stalks of acrocentric chromosome, activating synthetic processes of ribosomal genes
    1 context sentence
    Summary · context
    the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin in lymphocytes from old individuals

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  3. 03LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In cultured lymphocytes from old individuals, a pool of four peptide bioregulators including Epitalon did not deheterochromatinize pericentromeric structural heterochromatin.

    In plain wordsIn lab-grown lymphocytes from older donors, a group of four short peptides, including Epitalon, did not loosen one chromatin region.

    Peptide
    Epitalon
    Outcome
    No significant changePericentromeric structural heterochromatin
    Study

    humann: not reported in source

    Cultured lymphocytes from 75-88-year-old individuals
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    does not cause deheterochromatinized of pericentromeric structural heterochromatin
    1 context sentence
    Summary · context
    the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin in lymphocytes from old individuals

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 6 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Versions 3 to 5

    21 Oct 2026, 16:35 UTC

    The same notice was added 3 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 08:19 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.