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Study · Animal study (in vivo) · mouse · 2023

3 results

GHK peptide prevents sleep-deprived learning impairment in aging mice.

Rosenfeld M, Nickel K, Ladiges W

Aging pathobiology and therapeutics29 Mar 2023Cited by 7 (Europe PMC)

PMID37035833 (opens in a new tab)PMCIDPMC10081520 (opens in a new tab)DOI10.31491/apt.2023.03.109 (opens in a new tab)PepBankPUB-37035833
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sleep-deprived mice, GHK prevented acute learning impairment observed in saline-treated mice.

    In plain wordsIn mice with sleep deprivation, GHK prevented learning impairment compared with saline.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseAcute learning impairment
    Study

    micen: not reported in source

    Sleep-deprived aging mice
    Comparator
    Saline-treated sleep-deprived mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    15 mg/kg per day · injection · five daysAs given in this study (mice).

    Source sentences

    Summary
    Sleep-deprived mice treated with GHK did not show the acute learning impairment seen in sleep-deprived mice treated with saline.
    1 context sentence
    Summary · context
    In this study, mice were injected with 15 mg/kg GHK per day for five days and sleep deprived on the last two days of treatment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sleep-deprived mice, GHK prevented increased hippocampal MCP-1 levels compared with saline treatment.

    In plain wordsIn sleep-deprived mice, GHK prevented increased hippocampal MCP-1 levels compared with saline treatment.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseHippocampal MCP-1 levels
    Study

    micen: not reported in source

    Sleep-deprived aging mice
    Comparator
    Saline-treated sleep-deprived mice
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    15 mg/kg per day · injection · five daysAs given in this study (mice).

    Source sentences

    Summary
    GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivation.
    1 context sentence
    Summary · context
    In this study, mice were injected with 15 mg/kg GHK per day for five days and sleep deprived on the last two days of treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In sleep-deprived mice, GHK prevented increased hippocampal nitrotyrosine levels compared with saline treatment.

    In plain wordsIn sleep-deprived mice, GHK prevented increased hippocampal nitrotyrosine levels compared with saline treatment.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseHippocampal nitrotyrosine levels
    Study

    micen: not reported in source

    Sleep-deprived aging mice
    Comparator
    Saline-treated sleep-deprived mice
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    15 mg/kg per day · injection · five daysAs given in this study (mice).

    Source sentences

    Summary
    GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivation.
    1 context sentence
    Summary · context
    In this study, mice were injected with 15 mg/kg GHK per day for five days and sleep deprived on the last two days of treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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