Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats.

Gurbuz P, Duzova H, Taslidere AC, Gul CC

Biotechnic & histochemistry : official publication of the Biological Stain Commission22 Mar 2023Cited by 6 (Europe PMC)

PMID36946173DOI10.1080/10520295.2023.2187460PepBankPUB-36946173

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic pubertal rats, noopept alone reduced diabetes-induced pathological changes compared with diabetic controls.
In plain wordsIn diabetic rats, noopept alone reduced pathological changes compared with diabetic controls.
Peptide
Noopept (omberacetam)
Outcome
DecreaseDiabetes-induced pathological changes
Study
ratn: not reported in source
Streptozotocin-induced prepubertal diabetic male rats
Comparator
Diabetic control
Outcome group
Diabetes complications · Whole body
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
The D + I, D + N and D + I + N groups exhibited fewer DM induced pathological changes than the DC group.
2 context sentences(design, population, supporting numbers)
Summary · context
We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N).
Summary · context
Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days.
Report a problemFND-3694617301

Studies that did not test the peptide alone4

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

02AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pubertal rats, insulin plus noopept reduced diabetes-induced pathological changes compared with diabetic controls.
In plain wordsIn diabetic rats, insulin plus noopept reduced pathological changes compared with diabetic controls.
Peptide
Noopept (omberacetam)
Outcome
DecreaseDiabetes-induced pathological changes with insulin combination
Study
ratn: not reported in source
Streptozotocin-induced prepubertal diabetic male rats
Comparator
Diabetic control
Outcome group
Diabetes complications · Whole body
Source sentences
Summary
The D + I, D + N and D + I + N groups exhibited fewer DM induced pathological changes than the DC group.
2 context sentences(design, population, supporting numbers)
Summary · context
We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N).
Summary · context
Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3694617302
03AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pubertal rats, insulin plus noopept did not significantly change renal tubule diameter compared with diabetic controls.
In plain wordsIn diabetic rats, insulin plus noopept did not significantly change kidney tubule diameter compared with diabetic controls.
Peptide
Noopept (omberacetam)
Outcome
No significant changeRenal tubule diameter
Study
ratn: not reported in source
Streptozotocin-induced prepubertal diabetic male rats
Comparator
Diabetic control
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group.
2 context sentences(design, population, supporting numbers)
Summary · context
We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N).
Summary · context
Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3694617303
04AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pubertal rats, insulin plus noopept did not significantly change corneal thickness compared with diabetic controls.
In plain wordsIn diabetic rats, insulin plus noopept did not significantly change corneal thickness compared with diabetic controls.
Peptide
Noopept (omberacetam)
Outcome
No significant changeCorneal thickness
Study
ratn: not reported in source
Streptozotocin-induced prepubertal diabetic male rats
Comparator
Diabetic control
Outcome group
Vision and retina · Eye
Source sentences
Summary
The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group.
2 context sentences(design, population, supporting numbers)
Summary · context
We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N).
Summary · context
Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3694617304
05AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pubertal rats, insulin plus noopept did not significantly change retinal thickness compared with diabetic controls.
In plain wordsIn diabetic rats, insulin plus noopept did not significantly change retinal thickness compared with diabetic controls.
Peptide
Noopept (omberacetam)
Outcome
No significant changeRetinal thickness
Study
ratn: not reported in source
Streptozotocin-induced prepubertal diabetic male rats
Comparator
Diabetic control
Outcome group
Vision and retina · Eye
Source sentences
Summary
The D + I + N group exhibited no significant differences in renal tubule diameter and corneal and retinal thickness compared to the DC group.
2 context sentences(design, population, supporting numbers)
Summary · context
We allocated 60 prepubertal male rats randomly into six groups of 10: untreated control (C), DM control (DC), noopept control (NC), DM + noopept (D + N), DM + insulin (D + I) and DM + insulin + noopept (D + I + N).
Summary · context
Noopept was administered to the NC, D + N and D + I + N groups; insulin was administered to the D + I and D + I + N groups for 14 days.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3694617305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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