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Study · In vitro (cells) · 2023

5 results

Novel evidence of Thymosin α1 immunomodulatory properties in SARS-CoV-2 infection: Effect on innate inflammatory response in a peripheral blood mononuclear cell-based in vitro model.

Ricci D, Etna MP, Severa M, Fiore S, Rizzo F, Iannetta M, Andreoni M, Balducci S, Stefanelli P, Palamara AT, Coccia EM

International immunopharmacology13 Mar 2023Cited by 6 (Europe PMC)

PMID36933449 (opens in a new tab)PMCIDPMC10008813 (opens in a new tab)DOI10.1016/j.intimp.2023.109996 (opens in a new tab)PepBankPUB-36933449
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In SARS-CoV-2-stimulated PBMC cultures, thymosin alpha‑1 dampened the inflammatory and activation status of monocytes and myeloid dendritic cells.

    In plain wordsIn cells in a dish, thymosin alpha‑1 reduced the inflammatory state of immune cells that were stimulated with SARS-CoV-2.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMonocyte and myeloid dendritic cell inflammatory/activation status
    Study

    humann: not reported in source

    PBMC cultures stimulated with SARS-CoV-2
    Comparator
    Untreated SARS-CoV-2-stimulated PBMC
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the treatment of SARS-CoV-2-stimulated PBMC with Tα1 dampened the inflammatory/activation status of both monocytes and mDC by reducing the release of pro-inflammatory mediators, including TNF-α, IL-6 and IL-8, while promoting the production of the anti-inflammatory cytokine IL-10.
    1 context sentence
    Summary · context
    Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC).
  2. 02LabIn vitro (cells)Activity measurement

    In SARS-CoV-2-stimulated PBMC cultures, thymosin alpha‑1 reduced release of TNF-α.

    In plain wordsIn cells in a dish, thymosin alpha‑1 lowered the release of the inflammatory signal TNF-α.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTNF-α release
    Study

    humann: not reported in source

    PBMC cultures stimulated with SARS-CoV-2
    Comparator
    Untreated SARS-CoV-2-stimulated PBMC
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the treatment of SARS-CoV-2-stimulated PBMC with Tα1 dampened the inflammatory/activation status of both monocytes and mDC by reducing the release of pro-inflammatory mediators, including TNF-α, IL-6 and IL-8, while promoting the production of the anti-inflammatory cytokine IL-10.
    1 context sentence
    Summary · context
    Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC).
  3. 03LabIn vitro (cells)Activity measurement

    In SARS-CoV-2-stimulated PBMC cultures, thymosin alpha‑1 reduced release of IL-6.

    In plain wordsIn cells in a dish, thymosin alpha‑1 lowered the release of the inflammatory signal IL-6.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-6 release
    Study

    humann: not reported in source

    PBMC cultures stimulated with SARS-CoV-2
    Comparator
    Untreated SARS-CoV-2-stimulated PBMC
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the treatment of SARS-CoV-2-stimulated PBMC with Tα1 dampened the inflammatory/activation status of both monocytes and mDC by reducing the release of pro-inflammatory mediators, including TNF-α, IL-6 and IL-8, while promoting the production of the anti-inflammatory cytokine IL-10.
    1 context sentence
    Summary · context
    Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC).
  4. 04LabIn vitro (cells)Activity measurement

    In SARS-CoV-2-stimulated PBMC cultures, thymosin alpha‑1 reduced release of IL-8.

    In plain wordsIn cells in a dish, thymosin alpha‑1 lowered the release of the inflammatory signal IL-8.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-8 release
    Study

    humann: not reported in source

    PBMC cultures stimulated with SARS-CoV-2
    Comparator
    Untreated SARS-CoV-2-stimulated PBMC
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the treatment of SARS-CoV-2-stimulated PBMC with Tα1 dampened the inflammatory/activation status of both monocytes and mDC by reducing the release of pro-inflammatory mediators, including TNF-α, IL-6 and IL-8, while promoting the production of the anti-inflammatory cytokine IL-10.
    1 context sentence
    Summary · context
    Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC).
  5. 05LabIn vitro (cells)Activity measurement

    In SARS-CoV-2-stimulated PBMC cultures, thymosin alpha‑1 promoted production of the anti-inflammatory cytokine IL-10.

    In plain wordsIn cells in a dish, thymosin alpha‑1 raised the production of the anti-inflammatory signal IL-10.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-10 production
    Study

    humann: not reported in source

    PBMC cultures stimulated with SARS-CoV-2
    Comparator
    Untreated SARS-CoV-2-stimulated PBMC
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the treatment of SARS-CoV-2-stimulated PBMC with Tα1 dampened the inflammatory/activation status of both monocytes and mDC by reducing the release of pro-inflammatory mediators, including TNF-α, IL-6 and IL-8, while promoting the production of the anti-inflammatory cytokine IL-10.
    1 context sentence
    Summary · context
    Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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