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Study · Randomized controlled trial · n = 73 · 2023

4 results

Oxytocin has sex-specific effects on trust and underlying neurophysiological processes.

Schiller B, Brustkern J, Walker M, Hamm A, Heinrichs M

Psychoneuroendocrinology6 Mar 2023Cited by 20 (Europe PMC)

PMID36931056 (opens in a new tab)DOI10.1016/j.psyneuen.2023.106076 (opens in a new tab)PepBankPUB-36931056
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In heterosexual women, intranasal oxytocin reduced trust in a trust game versus placebo when trustees showed weak signals of attractiveness and threat.

    In plain wordsIn women, oxytocin nasal spray lowered trust in a trust game compared with placebo when trustee cues were weak.

    Peptide
    Oxytocin
    Outcome
    DecreaseTrust behavior in women (trust game)
    Study

    n = 73

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    On a behavioral level, we observed that OT increased trust in men and reduced it in women when trustees showed weak signals of attractiveness and threat.
    2 context sentences
    Summary · context
    Here, we studied sex differences in OT's effects on human trust behavior in 144 heterosexual participants (73 women, 71 men).
    Summary · context
    Participants received 24 international units of intranasal OT or placebo treatment and played a trust game in the role of the investor while undergoing electroencephalography.
  2. 02HumanRandomized controlled trialMechanism

    In heterosexual women, intranasal oxytocin dampened the early visual P100 EEG component versus placebo.

    In plain wordsIn women, oxytocin nasal spray weakened an early brain response seen on EEG, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseP100 EEG component in women
    Study

    n = 73

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Correspondingly, on the neurophysiological level, we noted that OT intensified the P100 in male participants, but dampened it in female ones.
    2 context sentences
    Summary · context
    Here, we studied sex differences in OT's effects on human trust behavior in 144 heterosexual participants (73 women, 71 men).
    Summary · context
    Participants received 24 international units of intranasal OT or placebo treatment and played a trust game in the role of the investor while undergoing electroencephalography.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In heterosexual men, intranasal oxytocin increased trust in a trust game versus placebo when trustees showed weak signals of attractiveness and threat.

    In plain wordsIn men, oxytocin nasal spray raised trust in a trust game more than placebo when trustee cues were weak.

    Peptide
    Oxytocin
    Outcome
    IncreaseTrust behavior in men (trust game)
    Study

    n = 71

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    On a behavioral level, we observed that OT increased trust in men and reduced it in women when trustees showed weak signals of attractiveness and threat.
    2 context sentences
    Summary · context
    Here, we studied sex differences in OT's effects on human trust behavior in 144 heterosexual participants (73 women, 71 men).
    Summary · context
    Participants received 24 international units of intranasal OT or placebo treatment and played a trust game in the role of the investor while undergoing electroencephalography.
  4. 04HumanRandomized controlled trialMechanism

    In heterosexual men, intranasal oxytocin intensified the early visual P100 EEG component versus placebo.

    In plain wordsIn men, oxytocin nasal spray strengthened an early brain response seen on EEG, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseP100 EEG component in men
    Study

    n = 71

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Correspondingly, on the neurophysiological level, we noted that OT intensified the P100 in male participants, but dampened it in female ones.
    2 context sentences
    Summary · context
    Here, we studied sex differences in OT's effects on human trust behavior in 144 heterosexual participants (73 women, 71 men).
    Summary · context
    Participants received 24 international units of intranasal OT or placebo treatment and played a trust game in the role of the investor while undergoing electroencephalography.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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