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Study · Randomized controlled trial · 2023

2 results

Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.

Aruan RR, Hutabarat H, Widodo AA, Firdiyono MTCC, Wirawanty C, Fransiska L

The Journal of clinical and aesthetic dermatology1 Feb 2023Cited by 3 (Europe PMC)

PMID36909866 (opens in a new tab)PMCIDPMC10005804 (opens in a new tab)PepBankPUB-36909866
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In Indonesian women with crow's feet, several subjects using PPP-4 cream showed improvement in clinical photos and data.

    In plain wordsIn Indonesian women with crow's feet, several PPP-4 cream users showed improvement in photographs and data.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    IncreaseClinical improvement in crow's feet
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · eight weeksAs given in this study (human).

    Source sentences

    Summary
    Based on clinical photos and data, improvements were found in several subjects using AHP-3 and PPP-4.
    1 context sentence
    Summary · context
    This study was a double-blind randomized trial using 21 Indonesian female subjects aged 26 to 55 years for eight weeks and divided into three groups: AHP-3 cream, PPP-4 cream, and placebo. The cream was applied twice daily to the periorbital area.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In Indonesian women with crow's feet, PPP-4 appeared better than AHP-3 based on data, photographs, and self-assessment.

    In plain wordsIn Indonesian women with crow's feet, PPP-4 appeared better than AHP-3 in data, photographs, and self-assessment.

    Peptide
    Matrixyl (palmitoyl pentapeptide-4)
    Outcome
    IncreaseOverall results versus AHP-3
    Study

    n: not reported in source

    Comparator
    AHP-3 cream
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · topical · eight weeksAs given in this study (human).

    Source sentences

    Summary
    PPP-4 appeared to demonstrate better results when compared to AHP-3 based on data, clinical photos, and self-assessment questionnaire.
    1 context sentence
    Summary · context
    This study was a double-blind randomized trial using 21 Indonesian female subjects aged 26 to 55 years for eight weeks and divided into three groups: AHP-3 cream, PPP-4 cream, and placebo. The cream was applied twice daily to the periorbital area.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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