Synergistic effects of combined therapy with cerebrolysin and enriched environment on anxiety-like behavior and spatial cognitive deficits in posttraumatic stress disorder-like mouse model.

Hosseini L, Sadigh-Eteghad S, Farajdokht F, Salehi-Pourmehr H, Pasokh A, Ziaee M, Sandoghchian Shotorbani S, Hosseini MJ, Mahmoudi J

Behavioural pharmacology10 Feb 2023Cited by 5 (Europe PMC)

PMID36853847DOI10.1097/fbp.0000000000000722PepBankPUB-36853847

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In PTSD-like mice, CBL alone reduced anxiety.
In plain wordsIn mice with PTSD-like symptoms, CBL alone reduced anxiety.
Peptide
Cerebrolysin
Outcome
DecreaseAnxiety
Study
mousen: not reported in source
PTSD-like Balb/c mice
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
2.5 mL/kg · 14 consecutive daysAs given in this study (mouse).
Source sentences
Summary
Our findings indicated that CBL, separately or in combination with EE, is effective in reducing anxiety and spatial memory impairment in PTSD-like mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations.
Summary · context
For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days.
Summary · context
Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days.
Report a problemFND-3685384702
02AnimalAnimal study (in vivo)Efficacy outcome
In PTSD-like mice, CBL alone reduced spatial memory impairment.
In plain wordsIn mice with PTSD-like symptoms, CBL alone reduced spatial memory impairment.
Peptide
Cerebrolysin
Outcome
DecreaseSpatial memory impairment
Study
mousen: not reported in source
PTSD-like Balb/c mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 mL/kg · 14 consecutive daysAs given in this study (mouse).
Source sentences
Summary
Our findings indicated that CBL, separately or in combination with EE, is effective in reducing anxiety and spatial memory impairment in PTSD-like mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations.
Summary · context
For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days.
Summary · context
Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days.
Report a problemFND-3685384703

Studies that did not test the peptide alone3

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In PTSD-like mice, CBL and/or its combination with enriched environment reversed molecular alterations.
In plain wordsIn mice with PTSD-like symptoms, CBL and/or its combination with enriched environment reversed molecular alterations.
Peptide
Cerebrolysin
Outcome
Direction not reportedMolecular alterations
Study
mousen: not reported in source
PTSD-like Balb/c mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations.
2 context sentences(design, population, supporting numbers)
Summary · context
For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days.
Summary · context
Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3685384701
04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In PTSD-like mice, CBL with enriched environment reduced anxiety.
In plain wordsIn mice with PTSD-like symptoms, CBL with enriched environment reduced anxiety.
Peptide
Cerebrolysin
Outcome
DecreaseCombination anxiety
Study
mousen: not reported in source
PTSD-like Balb/c mice
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Our findings indicated that CBL, separately or in combination with EE, is effective in reducing anxiety and spatial memory impairment in PTSD-like mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations.
Summary · context
For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days.
Summary · context
Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3685384704
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In PTSD-like mice, CBL with enriched environment reduced spatial memory impairment.
In plain wordsIn mice with PTSD-like symptoms, CBL with enriched environment reduced spatial memory impairment.
Peptide
Cerebrolysin
Outcome
DecreaseCombination spatial memory impairment
Study
mousen: not reported in source
PTSD-like Balb/c mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Our findings indicated that CBL, separately or in combination with EE, is effective in reducing anxiety and spatial memory impairment in PTSD-like mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations.
Summary · context
For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days.
Summary · context
Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3685384705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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