Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson's disease induced by reserpine.

Tharwat EK, Abdelaty AO, Abdelrahman AI, Elsaeed H, Elgohary A, El-Feky AS, Ebrahim YM, Sakraan A, Ismail HA, Khadrawy YA, Aboul Ezz HS, Noor NA and 5 more

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Fahmy HM, Mohammed HS, Mohammed FF, Radwan NM, Ahmed NA

Metabolic brain disease27 Feb 2023Cited by 6 (Europe PMC)

PMID36847968PMCIDPMC10185619DOI10.1007/s11011-023-01189-4PepBankPUB-36847968

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Summary

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present study aims to investigate the effects of cerebrolysin and/or lithium on the behavioral, neurochemical and histopathological alterations induced by reserpine as a model of PD. The rats were divided into control and reserpine-induced PD model groups. The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium. Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model. It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine. It could be suggested that cerebrolysin and/or lithium showed promising therapeutic potential against the variations induced in the reserpine model of PD. However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium. It can be concluded that the antioxidant and anti-inflammatory effects of both drugs played a significant role in their therapeutic potency.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study11

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin alone ameliorated neurochemical alterations less than lithium.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin alone improved neurochemical alterations less than lithium.
Peptide
Cerebrolysin
Outcome
DecreaseNeurochemical improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796806
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin alone ameliorated histopathological alterations less than lithium.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin alone improved tissue alterations less than lithium.
Peptide
Cerebrolysin
Outcome
DecreaseHistopathological improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796807
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin alone ameliorated behavioral alterations less than lithium.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin alone improved behavioral alterations less than lithium.
Peptide
Cerebrolysin
Outcome
DecreaseBehavioral improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796808
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium ameliorated neurochemical alterations less than lithium alone.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium improved neurochemical alterations less than lithium alone.
Peptide
Cerebrolysin
Outcome
DecreaseCombination neurochemical improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796809
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium ameliorated histopathological alterations less than lithium alone.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium improved tissue alterations less than lithium alone.
Peptide
Cerebrolysin
Outcome
DecreaseCombination histopathological improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796810
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium ameliorated behavioral alterations less than lithium alone.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin with lithium improved behavioral alterations less than lithium alone.
Peptide
Cerebrolysin
Outcome
DecreaseCombination behavioral improvement versus lithium
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Comparator
Lithium
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
Show in the study text Report a problemFND-3684796811

Studies that did not test the peptide alone5

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium ameliorated most oxidative stress alterations.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved most oxidative stress alterations.
Peptide
Cerebrolysin
Outcome
Direction not reportedOxidative stress parameters
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Show in the study text Report a problemFND-3684796801
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium ameliorated acetylcholinesterase alterations.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved acetylcholinesterase alterations.
Peptide
Cerebrolysin
Outcome
Direction not reportedAcetylcholinesterase
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Show in the study text Report a problemFND-3684796802
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium ameliorated monoamine alterations.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved monoamine alterations.
Peptide
Cerebrolysin
Outcome
Direction not reportedMonoamines
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Show in the study text Report a problemFND-3684796803
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium ameliorated nuclear factor-kappa changes.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved nuclear factor-kappa changes.
Peptide
Cerebrolysin
Outcome
Direction not reportedNuclear factor-kappa
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Show in the study text Report a problemFND-3684796804
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved histopathology.
In plain wordsIn rats with reserpine-induced Parkinson's disease, cerebrolysin and/or lithium improved tissue abnormalities.
Peptide
Cerebrolysin
Outcome
IncreaseHistopathology
Study
ratn: not reported in source
Reserpine-induced Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
The rats were divided into control and reserpine-induced PD model groups.
Summary · context
The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Show in the study text Report a problemFND-3684796805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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