Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: Behavioral and histopathological study.

Elhessy HM, Habotta OA, Eldesoqui M, Elsaed WM, Soliman MFM, Sewilam HM, Elhassan YH, Lashine NH

Frontiers in neuroanatomy1 Feb 2023Cited by 16 (Europe PMC)

PMID36816518PMCIDPMC9928760DOI10.3389/fnana.2023.1090738PepBankPUB-36816518

Summary

BackgroundThe majority of the suggested experimental modalities for peripheral nerve injury (PNI) result in varying degrees of recovery in animal models; however, there are not many reliable clinical pharmacological treatment models available. To alleviate PNI complications, research on approaches to accelerate peripheral nerve regeneration is encouraged. Cerebrolysin, dexamethasone, and ascorbic acid (vitamin C) drug models were selected in our study because of their reported curative effects of different mechanisms of action.MethodologyA total of 40 adult male albino rats were used in this study. Sciatic nerve crush injury was induced in 32 rats, which were divided equally into four groups (model, Cerebrolysin, dexamethasone, and vitamin C groups) and compared to the sham group (n = 8). The sciatic nerve sensory and motor function regeneration after crushing together with gastrocnemius muscle histopathological changes were evaluated by the sciatic function index, the hot plate test, gastrocnemius muscle mass ratio, and immune expression of S100 and apoptosis cascade (BAX, BCL2, and BAX/BCL2 ratio).ResultsSignificant improvement of the behavioral status and histopathological assessment scores occurred after the use of Cerebrolysin (as a neurotrophic factor), dexamethasone (as an anti-inflammatory), and vitamin C (as an antioxidant). Despite these seemingly concomitant, robust behavioral and pathological changes, vitamin C appeared to have the best results among the three main outcome measures. There was a positive correlation between motor and sensory improvement and also between behavioral and histopathological changes, boosting the effectiveness, and implication of the sciatic function index as a mirror for changes occurring on the tissue level.ConclusionVitamin C is a promising therapeutic in the treatment of PNI. The sciatic function index (SFI) test is a reliable accurate method for assessing sciatic nerve integrity after both partial disruption and regrowth.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with sciatic nerve injury, Cerebrolysin improved behavioral status.
In plain wordsIn rats with sciatic nerve injury, Cerebrolysin improved behavioral status.
Peptide
Cerebrolysin
Outcome
IncreaseBehavioral status
Study
ratn = 8
Sciatic nerve crush injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Significant improvement of the behavioral status and histopathological assessment scores occurred after the use of Cerebrolysin (as a neurotrophic factor), dexamethasone (as an anti-inflammatory), and vitamin C (as an antioxidant).
1 context sentence(design, population, supporting numbers)
Summary · context
Sciatic nerve crush injury was induced in 32 rats, which were divided equally into four groups (model, Cerebrolysin, dexamethasone, and vitamin C groups) and compared to the sham group (n = 8).
Show in the study text Report a problemFND-3681651801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with sciatic nerve injury, Cerebrolysin improved histopathological assessment scores.
In plain wordsIn rats with sciatic nerve injury, Cerebrolysin improved tissue assessment scores.
Peptide
Cerebrolysin
Outcome
IncreaseHistopathological assessment
Study
ratn = 8
Sciatic nerve crush injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Significant improvement of the behavioral status and histopathological assessment scores occurred after the use of Cerebrolysin (as a neurotrophic factor), dexamethasone (as an anti-inflammatory), and vitamin C (as an antioxidant).
1 context sentence(design, population, supporting numbers)
Summary · context
Sciatic nerve crush injury was induced in 32 rats, which were divided equally into four groups (model, Cerebrolysin, dexamethasone, and vitamin C groups) and compared to the sham group (n = 8).
Show in the study text Report a problemFND-3681651802

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Version history

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Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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