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Study · Randomized controlled trial · n = 50 · 2023

3 results

Effect of topical oxytocin gel on vaginal mucosa in postmenopausal Egyptian women: a clinical randomized trial.

Moussa A, Moberg KU, Elgrahy I, Elsayied M, Abdel-Rasheed M, Farouk M, Saad H, Meshaal H

The journal of sexual medicine1 Feb 2023Cited by 4 (Europe PMC)

PMID36763919 (opens in a new tab)DOI10.1093/jsxmed/qdac021 (opens in a new tab)PepBankPUB-36763919
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with vaginal atrophy, the vaginal mucosa shifted from pale to red in all 25 women on oxytocin gel but in only 4 on gel alone.

    In plain wordsIn postmenopausal women with vaginal atrophy, oxytocin gel turned the vaginal lining from pale to red in more women than gel alone.

    Peptide
    Oxytocin
    Outcome
    IncreaseColor of vaginal mucosa
    Study

    n = 50

    Comparator
    Gel alone (vehicle)
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    600 IU/mL · intravaginal · 2 weeksAs given in this study (human).

    Measurements

    Patients with mucosa color shift
    25 patients
    oxytocin gel
    Patients with mucosa color shift
    4 patients
    gel alone

    Source sentences

    Summary
    The color of the vaginal mucosa shifted from pale to red in all 25 patients treated with oxytocin but only in 4 patients in the control group (P < .001).
    2 context sentences
    Summary · context
    Fifty postmenopausal women aged 47 to 66 years with vaginal atrophy participated in this double-blinded placebo-controlled study.
    Summary · context
    The women were randomized to intravaginal treatment with either gel with 600 IU/mL of oxytocin (oxytocin group) or gel alone (control group) once daily for 2 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with vaginal atrophy, vaginal pH fell in both groups, and the fall was greater with oxytocin gel than with gel alone.

    In plain wordsIn postmenopausal women with vaginal atrophy, vaginal pH fell in both groups, but fell more with oxytocin gel than with gel alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseIntravaginal pH
    Study

    n = 50

    Comparator
    Gel alone (vehicle)
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    600 IU/mL · intravaginal · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    There was a significant decrease in intravaginal pH in the oxytocin group and the control group, with the delta value being significantly greater in the oxytocin group than in the control group (P < .001).
    2 context sentences
    Summary · context
    Fifty postmenopausal women aged 47 to 66 years with vaginal atrophy participated in this double-blinded placebo-controlled study.
    Summary · context
    The women were randomized to intravaginal treatment with either gel with 600 IU/mL of oxytocin (oxytocin group) or gel alone (control group) once daily for 2 weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with vaginal atrophy, the vaginal maturation index rose with oxytocin gel but not with gel alone.

    In plain wordsIn postmenopausal women with vaginal atrophy, vaginal cell maturation improved with oxytocin gel but not with gel alone.

    Peptide
    Oxytocin
    Outcome
    IncreaseVaginal maturation index
    Study

    n = 50

    Comparator
    Gel alone (vehicle)
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    600 IU/mL · intravaginal · 2 weeksAs given in this study (human).

    Source sentences

    Summary
    The vaginal maturation index increased significantly (P < .001) in the oxytocin group but not in the control group.
    2 context sentences
    Summary · context
    Fifty postmenopausal women aged 47 to 66 years with vaginal atrophy participated in this double-blinded placebo-controlled study.
    Summary · context
    The women were randomized to intravaginal treatment with either gel with 600 IU/mL of oxytocin (oxytocin group) or gel alone (control group) once daily for 2 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT05275270

Role of Topical Oxytocin Gel in Post-Menopausal Women

Al-Azhar Universityn = 501 Dec 2020 to 31 May 2021

Menopause Related Conditions

Trial pageClinicalTrials.govUpdated 11 Mar 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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