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Study · Randomized controlled trial · n = 90 · 2023

5 results

Prospective Randomized Control Trial to Compare the Role of Injection Cerebrolysin for 10 Days Duration Against Placebo in Operated Cases of Degenerative Cervical Myelopathy.

Sharma A, Agrawal H, Naseem A, Marathe N, Gajbhiye K, Subramanian S, Rocos B

Spine15 Nov 2022Cited by 5 (Europe PMC)

PMID36730671 (opens in a new tab)DOI10.1097/brs.0000000000004542 (opens in a new tab)PepBankPUB-36730671
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In operated DCM patients, mJOA scores improved at all follow-up times in both Cerebrolysin and placebo groups.

    In plain wordsIn operated DCM patients, mJOA scores improved from preoperative scores in both Cerebrolysin and placebo groups.

    Peptide
    Cerebrolysin
    Outcome
    IncreasemJOA improvement over follow-up
    Study

    n = 90

    Comparator
    Preoperative scores
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 daysAs given in this study (human).

    Source sentences

    Summary
    Both groups experienced an improvement in mJOA and VAS scores at all time-points during follow-up as compared with preoperative scores.
    3 context sentences
    Summary · context
    Ninety operated cases of mild to severe DCM were randomized into two groups.
    Summary · context
    Sixty patients received the injection Cerebrolysin for 10 days postoperatively.
    Summary · context
    The remaining 30 patients received a placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In operated DCM patients, VAS scores improved at all follow-up times in both Cerebrolysin and placebo groups.

    In plain wordsIn operated DCM patients, VAS scores improved from preoperative scores in both Cerebrolysin and placebo groups.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedVAS improvement over follow-up
    Study

    n = 90

    Comparator
    Preoperative scores
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · 10 daysAs given in this study (human).

    Source sentences

    Summary
    Both groups experienced an improvement in mJOA and VAS scores at all time-points during follow-up as compared with preoperative scores.
    3 context sentences
    Summary · context
    Ninety operated cases of mild to severe DCM were randomized into two groups.
    Summary · context
    Sixty patients received the injection Cerebrolysin for 10 days postoperatively.
    Summary · context
    The remaining 30 patients received a placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In operated DCM patients, Cerebrolysin produced greater mJOA scores than placebo at one year.

    In plain wordsIn operated DCM patients, Cerebrolysin produced higher mJOA scores than placebo at one year.

    Peptide
    Cerebrolysin
    Outcome
    IncreasemJOA at one year
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 daysAs given in this study (human).

    Measurements

    mJOA
    16.37 score
    Cerebrolysin
    mJOA
    15.2 score
    Placebo
    mJOA reported ± uncertainty term (type not specified)
    1 score
    Cerebrolysin, one-year follow-up, reported as 16.37±1
    mJOA reported ± uncertainty term (type not specified)
    1.8 score
    Placebo, one-year follow-up, reported as 15.2±1.8
    p value for mJOA comparison
    < 0.0001
    Cerebrolysin versus placebo, one-year follow-up

    Source sentences

    Summary
    However, the cerebrolysin group demonstrated significantly greater mJOA scores (16.37±1) when compared with the placebo (15.2±1.8) at one-year follow-up ( P <0.0001).
    3 context sentences
    Summary · context
    Ninety operated cases of mild to severe DCM were randomized into two groups.
    Summary · context
    Sixty patients received the injection Cerebrolysin for 10 days postoperatively.
    Summary · context
    The remaining 30 patients received a placebo.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In operated DCM patients, neurological improvement was superior with Cerebrolysin compared with placebo.

    In plain wordsIn operated DCM patients, neurological improvement was greater with Cerebrolysin than placebo.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeurological improvement
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 daysAs given in this study (human).

    Measurements

    p value for neurological improvement comparison
    0.04
    Cerebrolysin versus placebo

    Source sentences

    Summary
    Neurological improvement with cerebrolysin therapy was also superior ( P =0.04).
    3 context sentences
    Summary · context
    Ninety operated cases of mild to severe DCM were randomized into two groups.
    Summary · context
    Sixty patients received the injection Cerebrolysin for 10 days postoperatively.
    Summary · context
    The remaining 30 patients received a placebo.
  5. 05HumanRandomized controlled trialSafety outcome

    In operated DCM patients, no significant adverse reactions were documented with Cerebrolysin.

    In plain wordsIn operated DCM patients, the study documented no significant adverse reactions with Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSignificant adverse reactions
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 10 daysAs given in this study (human).

    Source sentences

    Summary
    No significant adverse reactions were documented.
    3 context sentences
    Summary · context
    Ninety operated cases of mild to severe DCM were randomized into two groups.
    Summary · context
    Sixty patients received the injection Cerebrolysin for 10 days postoperatively.
    Summary · context
    The remaining 30 patients received a placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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