Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.

Siecinski SK, Giamberardino SN, Spanos M, Hauser AC, Gibson JR, Chandrasekhar T, Trelles MDP, Rockhill CM, Palumbo ML, Cundiff AW, Montgomery A, Siper P and 26 more

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Minjarez M, Nowinski LA, Marler S, Kwee LC, Shuffrey LC, Alderman C, Weissman J, Zappone B, Mullett JE, Crosson H, Hong N, Luo S, She L, Bhapkar M, Dean R, Scheer A, Johnson JL, King BH, McDougle CJ, Sanders KB, Kim SJ, Kolevzon A, Veenstra-VanderWeele J, Hauser ER, Sikich L, Gregory SG

Autism research : official journal of the International Society for Autism Research7 Jan 2023Cited by 10 (Europe PMC)

PMID36609850PMCIDPMC10023458DOI10.1002/aur.2884PepBankPUB-36609850

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyMechanism
In participants with autism spectrum disorder, genetic variants were newly associated with the body's own plasma oxytocin level, several in known ASD risk genes.
In plain wordsIn people with autism, some gene variants were linked to the body's own oxytocin level in blood.
Peptide
Oxytocin
Outcome
Not applicableGenetic variants associated with plasma oxytocin
Study
n = 290
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes.
1 context sentence(design, population, supporting numbers)
Summary · context
To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3660985001
02HumanEndogenous levelObservational studyMechanism
In participants with autism spectrum disorder, the body's own plasma oxytocin level was subtly but significantly associated with peripheral transcriptional activity and DNA-methylation profiles.
In plain wordsIn people with autism, the body's own oxytocin level in blood was linked to gene activity and DNA methylation patterns.
Peptide
Oxytocin
Outcome
Not applicablePlasma oxytocin and transcriptional activity or DNA methylation
Study
n = 290
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA-methylation profiles across several annotated gene sets.
1 context sentence(design, population, supporting numbers)
Summary · context
To carry out this analysis, we integrated genome-wide profiles of DNA-methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3660985002

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Version history

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Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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