MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.

Yuan J, Xu B, Ma J, Pang X, Fu Y, Liang M, Wang M, Pan Y, Duan Y, Tang M, Zhu B, Laher I, Li S

Life sciences28 Dec 2022Cited by 9 (Europe PMC)

PMID36584915DOI10.1016/j.lfs.2022.121330PepBankPUB-36584915

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment significantly increased heart weight.
In plain wordsIn rats, MOTS‑c raised heart weight compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseHeart weight
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c and aerobic training significantly increased heart weight and heart weight index (HWI) (all p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment significantly increased the heart weight index.
In plain wordsIn rats, MOTS‑c raised the heart weight index compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseHeart weight index
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
MOTS-c and aerobic training significantly increased heart weight and heart weight index (HWI) (all p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment thickened myocardial fibers, with a tendency of hypertrophy.
In plain wordsIn rats, MOTS‑c thickened heart muscle fibers, with a tendency toward growth of the heart muscle.
Peptide
MOTS-c
Outcome
IncreaseMyocardial fiber thickness
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Aerobic exercise and MOTS-c treatment thickened myocardial fibers, with a tendency of hypertrophy.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment significantly decreased heart rate compared with controls.
In plain wordsIn rats, MOTS‑c lowered heart rate compared with control rats.
Peptide
MOTS-c
Outcome
DecreaseHeart rate
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Heart rate (HR) (p < 0.001, p = 0.010, p = 0.011), the isovolumic diastolic time constant (Tau) (p < 0.001, p < 0.001, p < 0.001) in exercised (E), MOST-c treated (M) and their combination (ME) decreased significantly
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment significantly decreased the isovolumic diastolic time constant Tau compared with controls.
In plain wordsIn rats, MOTS‑c shortened the heart's relaxation time constant compared with control rats.
Peptide
MOTS-c
Outcome
DecreaseIsovolumic diastolic time constant (Tau)
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Heart rate (HR) (p < 0.001, p = 0.010, p = 0.011), the isovolumic diastolic time constant (Tau) (p < 0.001, p < 0.001, p < 0.001) in exercised (E), MOST-c treated (M) and their combination (ME) decreased significantly
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment significantly increased dP/dtmax compared with controls.
In plain wordsIn rats, MOTS‑c raised the peak rate of pressure rise in the heart compared with control rats.
Peptide
MOTS-c
Outcome
IncreasedP/dtmax
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
while the dP/dt_max (p min (p < 0.001, p < 0.001, p = 0.001) in groups E, M and ME were significantly higher than those in group C
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment gave significantly higher dP/dtmin than controls.
In plain wordsIn rats, MOTS‑c raised the dP/dtmin measure of heart relaxation compared with control rats.
Peptide
MOTS-c
Outcome
IncreasedP/dtmin
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
while the dP/dt_max (p min (p < 0.001, p < 0.001, p = 0.001) in groups E, M and ME were significantly higher than those in group C
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491507
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, MOTS‑c treatment did not change end-diastolic pressure.
In plain wordsIn rats, MOTS‑c did not change end-diastolic pressure compared with control rats.
Peptide
MOTS-c
Outcome
No significant changeEnd-diastolic pressure (EDP)
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
but EDP (p = 0.903, p = 0.708, p = 0.744) remained unchanged.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491508
09AnimalAnimal study (in vivo)Mechanism
In rats, C/EBPβ gene levels were significantly lower in MOTS‑c treated rats than in controls in transcriptomics sequencing.
In plain wordsIn rats, MOTS‑c lowered activity of the C/EBPβ gene compared with control rats.
Peptide
MOTS-c
Outcome
DecreaseC/EBPβ gene level in transcriptome sequencing
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Moreover, C/EBPβ gene levels were significantly decreased in the differential gene expression between groups C and M transcriptomics sequencing.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491509
10AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly increased ErbB4 mRNA levels.
In plain wordsIn rats, MOTS‑c raised ErbB4 gene activity compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseErbB4 mRNA
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The levels of ErbB4 mRNA (p < 0.001, p < 0.001, p < 0.001) and Gata4 mRNA (p < 0.001, p < 0.001, p = 0.001) in groups E, M and ME increased significantly, while C/EBPβ mRNA expression decreased significantly (p < 0.001, p = 0.002, p = 0.001), which was consistent with the results of transcriptome sequencing.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491510
11AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly increased Gata4 mRNA levels.
In plain wordsIn rats, MOTS‑c raised Gata4 gene activity compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseGata4 mRNA
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The levels of ErbB4 mRNA (p < 0.001, p < 0.001, p < 0.001) and Gata4 mRNA (p < 0.001, p < 0.001, p = 0.001) in groups E, M and ME increased significantly, while C/EBPβ mRNA expression decreased significantly (p < 0.001, p = 0.002, p = 0.001), which was consistent with the results of transcriptome sequencing.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491511
12AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly decreased C/EBPβ mRNA expression.
In plain wordsIn rats, MOTS‑c lowered C/EBPβ gene activity compared with control rats.
Peptide
MOTS-c
Outcome
DecreaseC/EBPβ mRNA
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The levels of ErbB4 mRNA (p < 0.001, p < 0.001, p < 0.001) and Gata4 mRNA (p < 0.001, p < 0.001, p = 0.001) in groups E, M and ME increased significantly, while C/EBPβ mRNA expression decreased significantly (p < 0.001, p = 0.002, p = 0.001), which was consistent with the results of transcriptome sequencing.
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491512
13AnimalAnimal study (in vivo)Mechanism
In rats, NRG1 mRNA did not differ significantly between MOTS‑c treated rats and controls.
In plain wordsIn rats, MOTS‑c did not change NRG1 gene activity compared with control rats.
Peptide
MOTS-c
Outcome
No significant changeNRG1 mRNA
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
NRG1 mRNA in group E was significantly higher than that in group C (p = 0.003), but there was no significant difference between groups M and ME (p = 0.804, p = 0.320).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491513
14AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly increased NRG1 protein expression.
In plain wordsIn rats, MOTS‑c raised NRG1 protein compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseNRG1 protein expression
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The protein expression of NRG1 (p = 0.026, p < 0.001, p < 0.001), ErbB4 (p < 0.001, p < 0.001, p < 0.001) and Gata4 (p = 0.014, p < 0.001, p = 0.006) in groups E, M and ME increased significantly, while C/EBPβ decreased significantly (p < 0.001, p = 0.001, p = 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491514
15AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly increased ErbB4 protein expression.
In plain wordsIn rats, MOTS‑c raised ErbB4 protein compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseErbB4 protein expression
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The protein expression of NRG1 (p = 0.026, p < 0.001, p < 0.001), ErbB4 (p < 0.001, p < 0.001, p < 0.001) and Gata4 (p = 0.014, p < 0.001, p = 0.006) in groups E, M and ME increased significantly, while C/EBPβ decreased significantly (p < 0.001, p = 0.001, p = 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491515
16AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly increased Gata4 protein expression.
In plain wordsIn rats, MOTS‑c raised Gata4 protein compared with control rats.
Peptide
MOTS-c
Outcome
IncreaseGata4 protein expression
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The protein expression of NRG1 (p = 0.026, p < 0.001, p < 0.001), ErbB4 (p < 0.001, p < 0.001, p < 0.001) and Gata4 (p = 0.014, p < 0.001, p = 0.006) in groups E, M and ME increased significantly, while C/EBPβ decreased significantly (p < 0.001, p = 0.001, p = 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491516
17AnimalAnimal study (in vivo)Mechanism
In rats, MOTS‑c treatment significantly decreased C/EBPβ protein expression.
In plain wordsIn rats, MOTS‑c lowered C/EBPβ protein compared with control rats.
Peptide
MOTS-c
Outcome
DecreaseC/EBPβ protein expression
Study
ratn: not reported in source
Comparator
Control group (C)
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The protein expression of NRG1 (p = 0.026, p < 0.001, p < 0.001), ErbB4 (p < 0.001, p < 0.001, p < 0.001) and Gata4 (p = 0.014, p < 0.001, p = 0.006) in groups E, M and ME increased significantly, while C/EBPβ decreased significantly (p < 0.001, p = 0.001, p = 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We used Hematoxylin-Eosin staining(HE)and Transmission Electron Microscope (TEM) to observe the cardiac myocardial structure, carotid artery catheterization to test cardiac function, and real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting to describe the changes of NRG1,…
Report a problemFND-3658491517

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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