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Study · Animal study (in vivo) · rat · 2023

34 results

Abaloparatide and teriparatide enhance mandibular growth in adolescent rats with site-specific and mechano-related effects.

Wang R, Qiao H, Qian Y, Zhen G, Zhao Z, Li Y

European journal of orthodontics1 Mar 2023Cited by 4 (Europe PMC)

PMID36576115 (opens in a new tab)DOI10.1093/ejo/cjac069 (opens in a new tab)PepBankPUB-36576115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study34

28 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased condylar length.

    In plain wordsIn rats, abaloparatide alone increased condylar length.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCondylar length
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased condylar length.

    In plain wordsIn rats, teriparatide alone increased condylar length.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCondylar length
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased cartilage thickness.

    In plain wordsIn rats, abaloparatide alone increased cartilage thickness.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCartilage thickness
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased cartilage thickness.

    In plain wordsIn rats, teriparatide alone increased cartilage thickness.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage thickness
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased condylar SOX9 expression.

    In plain wordsIn rats, abaloparatide alone increased SOX9 expression in condylar cartilage.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCondylar SOX9 expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased condylar SOX9 expression.

    In plain wordsIn rats, teriparatide alone increased SOX9 expression in condylar cartilage.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCondylar SOX9 expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased condylar COL II expression.

    In plain wordsIn rats, abaloparatide alone increased COL II expression in condylar cartilage.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCondylar COL II expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased condylar COL II expression.

    In plain wordsIn rats, teriparatide alone increased COL II expression in condylar cartilage.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCondylar COL II expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone decreased condylar COL X expression.

    In plain wordsIn rats, abaloparatide alone decreased COL X expression in condylar cartilage.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseCondylar COL X expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone decreased condylar COL X expression.

    In plain wordsIn rats, teriparatide alone decreased COL X expression in condylar cartilage.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCondylar COL X expression
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased mandibular body height.

    In plain wordsIn rats, abaloparatide alone increased lower-jaw body height.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMandibular body height
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased mandibular body height.

    In plain wordsIn rats, teriparatide alone increased lower-jaw body height.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMandibular body height
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide alone increased mandibular angle width.

    In plain wordsIn rats, abaloparatide alone increased lower-jaw angle width.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMandibular angle width
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide alone increased mandibular angle width.

    In plain wordsIn rats, teriparatide alone increased lower-jaw angle width.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMandibular angle width
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.
  15. 15LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide enhanced proliferation.

    In plain wordsIn cells, abaloparatide enhanced jaw cartilage cell proliferation.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMCC proliferation
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  16. 16LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide enhanced proliferation.

    In plain wordsIn cells, teriparatide enhanced jaw cartilage cell proliferation.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMCC proliferation
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  17. 17LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide enhanced glycosaminoglycan synthesis.

    In plain wordsIn cells, abaloparatide enhanced glycosaminoglycan synthesis.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseGlycosaminoglycan synthesis
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  18. 18LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide enhanced glycosaminoglycan synthesis.

    In plain wordsIn cells, teriparatide enhanced glycosaminoglycan synthesis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseGlycosaminoglycan synthesis
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  19. 19LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide increased COL II expression.

    In plain wordsIn cells, abaloparatide increased COL II expression.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMCC COL II expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  20. 20LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide increased COL II expression.

    In plain wordsIn cells, teriparatide increased COL II expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMCC COL II expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  21. 21LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide increased SOX9 expression.

    In plain wordsIn cells, abaloparatide increased SOX9 expression.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMCC SOX9 expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  22. 22LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide increased SOX9 expression.

    In plain wordsIn cells, teriparatide increased SOX9 expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMCC SOX9 expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  23. 23LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide decreased COL X expression.

    In plain wordsIn cells, abaloparatide decreased COL X expression.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseMCC COL X expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  24. 24LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide decreased COL X expression.

    In plain wordsIn cells, teriparatide decreased COL X expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseMCC COL X expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  25. 25LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide decreased Ihh expression.

    In plain wordsIn cells, abaloparatide decreased Ihh expression.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseIhh expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  26. 26LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide decreased Ihh expression.

    In plain wordsIn cells, teriparatide decreased Ihh expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseIhh expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  27. 27LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, abaloparatide decreased PTH1R expression.

    In plain wordsIn cells, abaloparatide decreased PTH1R expression.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreasePTH1R expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.
  28. 28LabIn vitro (cells)Efficacy outcome

    In mandibular condylar chondrocytes, teriparatide decreased PTH1R expression.

    In plain wordsIn cells, teriparatide decreased PTH1R expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePTH1R expression
    Study

    n: not reported in source

    mandibular condylar chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, TPTD or ABL enhanced the MCC proliferation, glycosaminoglycan synthesis, COL II and SOX9 expression, whilst down-regulated COL X, Ihh and PTH1R expression.
    1 context sentence
    Summary · context
    Mandibular condylar chondrocytes (MCCs) were treated with TPTD or ABL, followed by CCK-8 assay, alcian blue staining, real time-PCR and immunofluorescent staining.

Studies that did not test the peptide alone6

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 29AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, mandibular advancement attenuated the promotive effects seen with abaloparatide alone.

    In plain wordsIn rats, mandibular advancement reduced the growth-promoting effects seen with abaloparatide alone.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseGrowth promotion with mandibular advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Comparator
    abaloparatide alone
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  2. 30AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, mandibular advancement attenuated the promotive effects seen with teriparatide alone.

    In plain wordsIn rats, mandibular advancement reduced the growth-promoting effects seen with teriparatide alone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseGrowth promotion with mandibular advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Comparator
    teriparatide alone
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In vivo, TPTD or ABL alone increased the condylar length and cartilage thickness, with up-regulated SOX9 and COL II, whilst down-regulated COL X; however, when combined with MA, the promotive effects were attenuated.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

  3. 31AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide combined with mandibular advancement increased mandibular body length.

    In plain wordsIn rats, abaloparatide combined with mandibular advancement increased lower-jaw body length.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMandibular body length with advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  4. 32AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide combined with mandibular advancement increased mandibular body length.

    In plain wordsIn rats, teriparatide combined with mandibular advancement increased lower-jaw body length.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMandibular body length with advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

  5. 33AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, abaloparatide combined with mandibular advancement increased alveolar bone width.

    In plain wordsIn rats, abaloparatide combined with mandibular advancement increased alveolar bone width.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseAlveolar bone width with advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  6. 34AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome

    In adolescent rats, teriparatide combined with mandibular advancement increased alveolar bone width.

    In plain wordsIn rats, teriparatide combined with mandibular advancement increased alveolar bone width.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseAlveolar bone width with advancement
    Study

    ratn: not reported in source

    adolescent Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    TPTD or ABL alone increased the mandibular body height and mandibular angle width, whilst increased the mandibular body length and alveolar bone width when combined with MA.
    1 context sentence
    Summary · context
    In total, 70 4-week-old male Sprague-Dawley rats were randomly divided into 14 groups, treated with intermittent TPDT or ABL at various doses, accompanied by mandibular advancement (MA) or not.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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