In chicken hepatocytes, experiments using AICAR or compound C supported cAMP/AMPK-mediated mTOR inhibition in DHEA-associated reduction of excess fat accumulation.
In plain wordsIn cells from chickens, experiments using AICAR supported an AMPK pathway mechanism for DHEA effects on fat accumulation.
- Peptide
- AICAR (acadesine)
- Outcome
- Not applicablecAMP/AMPK-mTOR involvement in DHEA action
- Study
chickenn: not reported in source
oleic acid-stimulated primary chicken hepatocytes- Outcome group
- Receptor activity and mechanism · Liver
Source sentences
the hepatocytes were pre-treated with AMPK inhibitor compound C or AMPK activator AICAR before addition of DHEA treatment, and the results certified that DHEA activated cAMP/AMPK pathway and which subsequently led the inhibition of mTOR signal, which finally reduced the fat excessive accumulation in…
1 context sentence(design, population, supporting numbers)
Herein, the present study aimed to investigate the regulatory effects and its molecular mechanism of DHEA on disturbance of lipid metabolism induced by oleic acid (OA) in primary chicken hepatocytes.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).