Skip to content

Study · Animal study (in vivo) · mouse · 2023

4 results

Differential effects of parathyroid hormone, parathyroid hormone-related protein, and abaloparatide on collagen 1 expression by mouse cementoblasts and mouse tooth root density.

Hsu C, He Z, Le Henaff C, Partridge NC

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics19 Dec 2022Cited by 1 (Europe PMC)

PMID36543659 (opens in a new tab)PMCIDPMC9991996 (opens in a new tab)DOI10.1016/j.ajodo.2021.12.023 (opens in a new tab)PepBankPUB-36543659
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide increased incisor root mineral density.

    In plain wordsIn mice, abaloparatide increased incisor root mineral density.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseIncisor root mineral density
    Study

    mousen: not reported in source

    mouse teeth
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Microcomputed tomography of teeth showed PTH (1-34) injections increased molar root mineral density in mice, whereas abaloparatide increased density in roots of incisors and molars.
    1 context sentence
    Summary · context
    Microcomputed tomography was performed on the teeth of mice receiving daily injections of phosphate-buffered saline, PTH (1-34), or abaloparatide.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide increased molar root mineral density.

    In plain wordsIn mice, abaloparatide increased molar root mineral density.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMolar root mineral density
    Study

    mousen: not reported in source

    mouse teeth
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Microcomputed tomography of teeth showed PTH (1-34) injections increased molar root mineral density in mice, whereas abaloparatide increased density in roots of incisors and molars.
    1 context sentence
    Summary · context
    Microcomputed tomography was performed on the teeth of mice receiving daily injections of phosphate-buffered saline, PTH (1-34), or abaloparatide.
  3. 03LabIn vitro (cells)Mechanism

    In mouse cementoblasts, abaloparatide and the other tested peptides regulated a gene panel, without separate directional results.

    In plain wordsIn cells from mice, abaloparatide and the other tested peptides regulated a gene panel without separate directional results.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Direction not reportedGene expression regulation
    Study

    mousen: not reported in source

    OCCM-30 cementoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 6 h/d for 3 daysAs given in this study (mouse).

    Source sentences

    Summary
    Gene expression showed regulation of Bsp, Col1a1, Opg, Rankl, and Mmp13 by the 3 peptides in these cells.
    1 context sentence
    Summary · context
    The murine cementoblast line, OCCM-30, known to express collagen I (Col1a1), was treated with intermittent PTH (1-34), PTHrP (1-36), or abaloparatide for 6 h/d for 3 days.
  4. 04LabIn vitro (cells)Mechanism

    In mouse cementoblasts, abaloparatide increased COL1A1 protein with a latent effect 18 hours after treatment.

    In plain wordsIn cells from mice, abaloparatide increased collagen protein 18 hours after treatment.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCOL1A1 protein
    Study

    mousen: not reported in source

    OCCM-30 cementoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 6 h/d for 3 daysAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, abaloparatide showed a latent effect in increasing COL1A1 protein 18 hours after treatment.
    1 context sentence
    Summary · context
    The murine cementoblast line, OCCM-30, known to express collagen I (Col1a1), was treated with intermittent PTH (1-34), PTHrP (1-36), or abaloparatide for 6 h/d for 3 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.