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Study · Randomized controlled trial · n = 112 · 2022

3 results

Oxytocin and Hypotension During Dilation and Evacuation Procedures at 18-24 Weeks Gestation.

Anderson CM, Tschann M, Whitehouse K, Soon R, Fontanilla T, Kaneshiro B

Hawai'i journal of health & social welfare1 Dec 2022Cited by 1 (Europe PMC)

PMID36504503 (opens in a new tab)PMCIDPMC9727702 (opens in a new tab)PepBankPUB-36504503
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In patients undergoing dilation and evacuation at 18-24 weeks, mean blood pressure did not differ between intravenous oxytocin and placebo.

    In plain wordsIn patients having a pregnancy-termination procedure, oxytocin did not change average blood pressure compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMean blood pressure
    Study

    n = 112

    Comparator
    Placebo (saline)
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    30 units · intravenous bolus · single bolusAs given in this study (human).

    Source sentences

    Summary
    No differences in demographic characteristics or mean blood pressure between the 2 groups were observed.
    2 context sentences
    Summary · context
    The secondary data from a double-blind, randomized, placebo-controlled trial involving 112 patients who underwent a D&E at 18-24 weeks gestation and prophylactically received an intravenous bolus of either 30 units of oxytocin in 500 mL of normal saline or 500 mL of saline alone at the start of the…
    Summary · context
    Anesthesia providers measured blood pressure before, at the time of, and after study medication administration in 5-minute increments until the end of the procedure.
  2. 02HumanRandomized controlled trialSafety outcome

    In patients undergoing dilation and evacuation at 18-24 weeks, the proportion with hypotension at 5 minutes was not significantly different with oxytocin (25%) versus placebo (13%).

    In plain wordsIn patients having a pregnancy-termination procedure, low blood pressure at 5 minutes was not significantly more common with oxytocin than with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeProportion hypotensive at 5 minutes
    Study

    n = 112

    Comparator
    Placebo (saline)
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    30 units · intravenous bolus · single bolusAs given in this study (human).

    Measurements

    Hypotensive patients
    25%
    oxytocin, 5 minutes
    Hypotensive patients
    13%
    placebo, 5 minutes

    Source sentences

    Summary
    The proportion of hypotensive patients was not statistically different at 5 minutes following fluid bolus (oxytocin 25% versus placebo 13%, P=.09).
    2 context sentences
    Summary · context
    The secondary data from a double-blind, randomized, placebo-controlled trial involving 112 patients who underwent a D&E at 18-24 weeks gestation and prophylactically received an intravenous bolus of either 30 units of oxytocin in 500 mL of normal saline or 500 mL of saline alone at the start of the…
    Summary · context
    Anesthesia providers measured blood pressure before, at the time of, and after study medication administration in 5-minute increments until the end of the procedure.
  3. 03HumanRandomized controlled trialSafety outcome

    In patients undergoing dilation and evacuation at 18-24 weeks, the proportion with hypotension at 10 minutes was similar with oxytocin (20%) and placebo (16%).

    In plain wordsIn patients having a pregnancy-termination procedure, low blood pressure at 10 minutes was similar with oxytocin and with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeProportion hypotensive at 10 minutes
    Study

    n = 112

    Comparator
    Placebo (saline)
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    30 units · intravenous bolus · single bolusAs given in this study (human).

    Measurements

    Hypotensive patients
    20%
    oxytocin, 10 minutes
    Hypotensive patients
    16%
    placebo, 10 minutes

    Source sentences

    Summary
    The proportion of hypotensive patients was similar by 10 minutes (oxytocin 20% versus placebo 16%, P=.62).
    2 context sentences
    Summary · context
    The secondary data from a double-blind, randomized, placebo-controlled trial involving 112 patients who underwent a D&E at 18-24 weeks gestation and prophylactically received an intravenous bolus of either 30 units of oxytocin in 500 mL of normal saline or 500 mL of saline alone at the start of the…
    Summary · context
    Anesthesia providers measured blood pressure before, at the time of, and after study medication administration in 5-minute increments until the end of the procedure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

MeSH terms

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