Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty.

Eisenach JC, Shields JS, Weller RS, Curry RS, Langfitt MK, Henshaw DS, Pollock DC, Edwards CJ, Houle TT

Pain19 Oct 2022Cited by 8 (Europe PMC)

PMID36448974PMCIDPMC10106358DOI10.1097/j.pain.0000000000002810PepBankPUB-36448974

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In adults after total hip arthroplasty, intrathecal oxytocin did not change the modelled pain trajectory compared with saline, on the day of discharge or over time.
In plain wordsIn adults after hip replacement, oxytocin given in the spinal fluid did not change pain compared with saline.
Peptide
Oxytocin
Outcome
No significant changeModelled pain trajectory
Study
n = 90
Comparator
Saline placebo
Analysis
Primary
Outcome group
Pain · Nervous system and cognition
Studied dose
100 μg · intrathecalAs given in this study (human).
Source sentences
Summary
Modelled pain trajectory, the primary analysis, did not differ between the groups, either in pain on day of hospital discharge (intercept: -0.1 [95% CI: -0.8 to 0.6], P = 0.746) or in reductions over time (slope: 0.1 pain units per log of time [95% CI: 0-0.2], P = 0.057).
1 context sentence(design, population, supporting numbers)
Summary · context
Ninety-eight individuals undergoing elective total hip arthroplasty were randomized to receive either intrathecal oxytocin (100 μg) or saline.
Report a problemFND-3644897401
02HumanRandomized controlled trialEfficacy outcome
In adults after total hip arthroplasty, postoperative opioid use ended earlier in the oxytocin group than in the saline group.
In plain wordsIn adults after hip replacement, opioid use ended earlier with spinal oxytocin than with saline.
Peptide
Oxytocin
Outcome
DecreaseDuration of postoperative opioid use
Study
n = 90
Comparator
Saline placebo
Analysis
Secondary
Outcome group
Pain · Nervous system and cognition
Studied dose
100 μg · intrathecalAs given in this study (human).
Source sentences
Summary
postoperative opioid use ended earlier in the oxytocin group
1 context sentence(design, population, supporting numbers)
Summary · context
Ninety-eight individuals undergoing elective total hip arthroplasty were randomized to receive either intrathecal oxytocin (100 μg) or saline.
Report a problemFND-3644897402
03HumanRandomized controlled trialEfficacy outcome
In adults after total hip arthroplasty, oxytocin-treated patients walked nearly 1000 more steps daily at 8 weeks than saline patients.
In plain wordsIn adults after hip replacement, patients given spinal oxytocin walked about 1000 more steps a day at 8 weeks than those given saline.
Peptide
Oxytocin
Outcome
IncreaseDaily steps at 8 weeks
Study
n = 90
Comparator
Saline placebo
Analysis
Secondary
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
100 μg · intrathecalAs given in this study (human).
Measurements
Additional daily steps
≈ 1000 steps
8 weeks
Source sentences
Summary
oxytocin-treated patients walked nearly 1000 more steps daily at 8 weeks ( P < 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
Ninety-eight individuals undergoing elective total hip arthroplasty were randomized to receive either intrathecal oxytocin (100 μg) or saline.
Report a problemFND-3644897403
04HumanRandomized controlled trialEfficacy outcome
In adults after total hip arthroplasty, intrathecal oxytocin gave a clinically meaningful reduction in disability for the first 21 postoperative days compared with saline.
In plain wordsIn adults after hip replacement, spinal oxytocin reduced disability in the first 21 days more than saline.
Peptide
Oxytocin
Outcome
DecreaseDisability in the first 21 postoperative days
Study
n = 90
Comparator
Saline placebo
Analysis
Secondary
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
100 μg · intrathecalAs given in this study (human).
Source sentences
Summary
exhibited a clinically meaningful reduction in disability for the first 21 postoperative days ( P = 0.007) compared with saline placebo.
1 context sentence(design, population, supporting numbers)
Summary · context
Ninety-eight individuals undergoing elective total hip arthroplasty were randomized to receive either intrathecal oxytocin (100 μg) or saline.
Report a problemFND-3644897404
05HumanRandomized controlled trialSafety outcome
In adults after total hip arthroplasty, intrathecal oxytocin caused no study drug-related adverse effects.
In plain wordsIn adults after hip replacement, spinal oxytocin caused no side effects that the study linked to the drug.
Peptide
Oxytocin
Outcome
No significant changeStudy drug-related adverse effects
Study
n = 90
Comparator
Saline placebo
Outcome group
Adverse events · Whole body
Studied dose
100 μg · intrathecalAs given in this study (human).
Source sentences
Summary
There were no study drug-related adverse effects.
1 context sentence(design, population, supporting numbers)
Summary · context
Ninety-eight individuals undergoing elective total hip arthroplasty were randomized to receive either intrathecal oxytocin (100 μg) or saline.
Report a problemFND-3644897405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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