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Study · Case report or series · n = 5 · 2022

3 results

Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation.

Villarreal-Reyna G, Garza-Morales R, Soto-Domínguez A, Montañez-Guerrero L, Saucedo-Cárdenas O, Gómez-Flores M, Ocampo-Garza JA, Pérez-Trujillo JJ, Montes-de-Oca-Luna R

European journal of medical research21 Nov 2022Cited by 2 (Europe PMC)

PMID36411485 (opens in a new tab)PMCIDPMC9677656 (opens in a new tab)DOI10.1186/s40001-022-00889-4 (opens in a new tab)PepBankPUB-36411485
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Summary

Hair graying, a prototypical sign of human aging, is a progressive loss of pigmentation from growing hair shafts caused by disease and as a side effect of medications. Cerebrolysin is a neuropeptide preparation that mimics the effect of endogenous neurotrophic factors. Cerebrolysin has been widely used in neurologic conditions, such as cerebral stroke, Alzheimer's disease, and dementia, among others. Cerebrolysin treatment has achieved to regain or maintain the cognitive ability of affected patients; however, up to date, there are no reports about the reactivation of hair pigmentation. We describe a previously not described effect occurring on patients receiving Cerebrolysin treatment for neurologic diseases and whether this effect is associated in reactivation of melanocytes and melanin expression. Here, we report five patients (mean age, 70.6 years), who also had age-related hair graying and scalp hair repigmentation during Cerebrolysin treatment. Macroscopic analysis revealed hair repigmentation consisted in diffuse darkening of the scalp hair. Impregnation and immunostaining analysis were performed on scalp biopsies taken before and after Cerebrolysin treatment; the results showed greater melanin and melanocyte marker MART-1/Melan-A staining following Cerebrolysin treatment. We present, to our knowledge, the first report on hair repigmentation is a previously not described effect occurring following Cerebrolysin treatment.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In five patients with age-related hair graying, scalp hair repigmentation occurred during Cerebrolysin treatment as diffuse darkening.

    In plain wordsIn five patients with gray hair, scalp hair became darker during Cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseScalp hair repigmentation
    Study

    n = 5

    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Macroscopic analysis revealed hair repigmentation consisted in diffuse darkening of the scalp hair.
    1 context sentence
    Summary · context
    Here, we report five patients (mean age, 70.6 years), who also had age-related hair graying and scalp hair repigmentation during Cerebrolysin treatment.
  2. 02HumanCase report or seriesEfficacy outcome

    In scalp biopsies from patients, melanin staining increased following Cerebrolysin treatment.

    In plain wordsIn patients, scalp biopsies showed greater melanin staining after Cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMelanin staining
    Study

    n: not reported in source

    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the results showed greater melanin and melanocyte marker MART-1/Melan-A staining following Cerebrolysin treatment.
    1 context sentence
    Summary · context
    Here, we report five patients (mean age, 70.6 years), who also had age-related hair graying and scalp hair repigmentation during Cerebrolysin treatment.
  3. 03HumanCase report or seriesEfficacy outcome

    In scalp biopsies from patients, MART-1/Melan-A staining increased following Cerebrolysin treatment.

    In plain wordsIn patients, scalp biopsies showed greater staining for a melanocyte marker after Cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMART-1/Melan-A staining
    Study

    n: not reported in source

    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the results showed greater melanin and melanocyte marker MART-1/Melan-A staining following Cerebrolysin treatment.
    1 context sentence
    Summary · context
    Here, we report five patients (mean age, 70.6 years), who also had age-related hair graying and scalp hair repigmentation during Cerebrolysin treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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