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Study · Randomized controlled trial · 2022

3 results

Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity during the encoding of episodic memories.

Coenjaerts M, Trimborn I, Adrovic B, Stoffel-Wagner B, Cahill L, Philipsen A, Hurlemann R, Scheele D

NeuroImage27 Oct 2022Cited by 11 (Europe PMC)

PMID36349596 (opens in a new tab)DOI10.1016/j.neuroimage.2022.119689 (opens in a new tab)PepBankPUB-36349596
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy women and men, intranasal oxytocin alone significantly diminished the sex difference in recognition memory seen under placebo.

    In plain wordsIn healthy men and women, oxytocin alone reduced the usual difference between the sexes in memory for pictures, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSex difference in recognition memory
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    The separate treatments with either hormone significantly diminished this mnemonic sex difference and reversed the hippocampal activation pattern.
    3 context sentences
    Summary · context
    Under placebo, women showed a significantly better recognition memory and increased hippocampal responses to subsequently remembered items independent of the emotional valence compared to men.
    Summary · context
    To this end, we conducted a randomized, placebo-controlled, parallel-group functional magnetic resonance imaging (fMRI) study including healthy free-cycling women (n = 111) and men (n = 115).
    Summary · context
    The fMRI session was conducted under four experimental conditions: 1. transdermal estradiol (2 mg) and intranasal oxytocin (24 IU), 2. transdermal placebo and intranasal oxytocin, 3. transdermal estradiol and intranasal placebo, 4. transdermal placebo and intranasal placebo.
  2. 02HumanRandomized controlled trialMechanism

    In healthy women and men, intranasal oxytocin alone reversed the sex-specific hippocampal activation pattern during encoding of episodic memories.

    In plain wordsIn healthy men and women, oxytocin alone reversed the usual difference between the sexes in hippocampal activity during memory encoding, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedHippocampal activation pattern during encoding
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    The separate treatments with either hormone significantly diminished this mnemonic sex difference and reversed the hippocampal activation pattern.
    3 context sentences
    Summary · context
    Under placebo, women showed a significantly better recognition memory and increased hippocampal responses to subsequently remembered items independent of the emotional valence compared to men.
    Summary · context
    To this end, we conducted a randomized, placebo-controlled, parallel-group functional magnetic resonance imaging (fMRI) study including healthy free-cycling women (n = 111) and men (n = 115).
    Summary · context
    The fMRI session was conducted under four experimental conditions: 1. transdermal estradiol (2 mg) and intranasal oxytocin (24 IU), 2. transdermal placebo and intranasal oxytocin, 3. transdermal estradiol and intranasal placebo, 4. transdermal placebo and intranasal placebo.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In healthy women and men, combined transdermal estradiol and intranasal oxytocin produced no significant effect on the sex difference in episodic memory.

    In plain wordsIn healthy men and women, estradiol and oxytocin together had no significant effect on memory differences between the sexes.

    Peptide
    Oxytocin
    Outcome
    No significant changeCombined estradiol and oxytocin treatment on memory sex difference
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    However, the combined treatments produced no significant effect.
    2 context sentences
    Summary · context
    To this end, we conducted a randomized, placebo-controlled, parallel-group functional magnetic resonance imaging (fMRI) study including healthy free-cycling women (n = 111) and men (n = 115).
    Summary · context
    The fMRI session was conducted under four experimental conditions: 1. transdermal estradiol (2 mg) and intranasal oxytocin (24 IU), 2. transdermal placebo and intranasal oxytocin, 3. transdermal estradiol and intranasal placebo, 4. transdermal placebo and intranasal placebo.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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