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Study · In vitro (cells) · 2022

5 results

Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress.

Avci S, Gunaydin S, Ari NS, Karaca Sulukoglu E, Polat OE, Gecili I, Yeni Y, Yilmaz A, Genc S, Hacimuftuoglu A, Yildirim S, Mokresh MY and 6 more

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Findik DG, Tsatsakis A, Margina D, Tsarouhas K, Wallace DR, Taghizadehghalehjoughi A

Journal of molecular neuroscience : MN4 Nov 2022Cited by 21 (Europe PMC)

PMID36333611 (opens in a new tab)DOI10.1007/s12031-022-02078-8 (opens in a new tab)PepBankPUB-36333611
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary cortex neuron culture, cerebrolysin decreased glutamate concentration in the synaptic cleft.

    In plain wordsIn cells, cerebrolysin decreased glutamate concentration around neurons.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSynaptic glutamate concentration
    Study

    n: not reported in source

    Primary cortex neuron culture
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · 24 and 48 hAs given in this study.

    Source sentences

    Summary
    Our data showed that cerebrolysin primarily protects neurons by decreasing glutamate concentration in the synaptic cleft.
    1 context sentence
    Summary · context
    Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h.
  2. 02LabIn vitro (cells)Efficacy outcome

    In primary cortex neuron culture, Cerebrolysin decreased oxidative stress.

    In plain wordsIn cells, Cerebrolysin decreased oxidative stress.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseOxidative stress
    Study

    n: not reported in source

    Primary cortex neuron culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 24 and 48 hAs given in this study.

    Source sentences

    Summary
    In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.
    1 context sentence
    Summary · context
    Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h.
  3. 03LabIn vitro (cells)Efficacy outcome

    In primary cortex neuron culture, Cerebrolysin decreased neuron cell damage.

    In plain wordsIn cells, Cerebrolysin decreased neuron damage.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNeuron cell damage
    Study

    n: not reported in source

    Primary cortex neuron culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 24 and 48 hAs given in this study.

    Source sentences

    Summary
    In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.
    1 context sentence
    Summary · context
    Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h.
  4. 04LabIn vitro (cells)Mechanism

    In primary cortex neuron culture, Cerebrolysin increased antioxidant activity.

    In plain wordsIn cells, Cerebrolysin increased antioxidant activity.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAntioxidant activity
    Study

    n: not reported in source

    Primary cortex neuron culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 24 and 48 hAs given in this study.

    Source sentences

    Summary
    In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.
    1 context sentence
    Summary · context
    Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h.
  5. 05LabIn vitro (cells)Mechanism

    In primary cortex neuron culture, Cerebrolysin decreased inflammatory cytokine levels.

    In plain wordsIn cells, Cerebrolysin decreased inflammatory cytokine levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseInflammatory cytokine levels
    Study

    n: not reported in source

    Primary cortex neuron culture
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · 24 and 48 hAs given in this study.

    Source sentences

    Summary
    In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.
    1 context sentence
    Summary · context
    Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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