Skip to content

Study · Animal study (in vivo) · mouse · 2022

9 results

TREM-1 exacerbates bleomycin-induced pulmonary fibrosis by aggravating alveolar epithelial cell senescence in mice.

Xiong JB, Duan JX, Jiang N, Zhang CY, Zhong WJ, Yang JT, Liu YB, Su F, Zhou Y, Li D, Yang HH, Guan CX

International immunopharmacology27 Oct 2022Cited by 20 (Europe PMC)

PMID36330909 (opens in a new tab)DOI10.1016/j.intimp.2022.109339 (opens in a new tab)PepBankPUB-36330909
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis, prophylactic LR12 increased survival.

    In plain wordsIn mice with bleomycin-induced lung fibrosis, preventive LR12 increased survival.

    Peptide
    Nangibotide
    Outcome
    IncreaseSurvival with prophylactic blockade
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Mortality · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis, prophylactic LR12 attenuated tissue injury.

    In plain wordsIn mice with bleomycin-induced lung fibrosis, preventive LR12 reduced tissue injury.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung tissue injury with prophylactic blockade
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis, prophylactic LR12 reduced extracellular matrix deposition.

    In plain wordsIn mice with bleomycin-induced lung fibrosis, preventive LR12 reduced extracellular matrix deposits.

    Peptide
    Nangibotide
    Outcome
    DecreaseExtracellular matrix deposition with prophylactic blockade
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, early therapeutic TREM-1 blockade with LR12 attenuated bleomycin-induced pulmonary fibrosis.

    In plain wordsIn mice, early treatment with LR12 reduced bleomycin-induced lung fibrosis.

    Peptide
    Nangibotide
    Outcome
    DecreasePulmonary fibrosis with therapeutic blockade
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, therapeutic blockade of TREM-1 at the early stage of fibrosis also attenuated BLM-induced PF, suggesting a non-inflammatory effect.
    1 context sentence
    Summary · context
    Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with pulmonary fibrosis, LR12 significantly reduced lung p16 expression.

    In plain wordsIn mice with lung fibrosis, LR12 reduced lung p16 expression.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung p16 expression
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    More importantly, we observed that TREM-1 blockade with LR12 significantly reduced the expression of the senescence-relative protein, including p16, p21, p53, and γ-H2AX in the lungs of PF mice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with pulmonary fibrosis, LR12 significantly reduced lung p21 expression.

    In plain wordsIn mice with lung fibrosis, LR12 reduced lung p21 expression.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung p21 expression
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    More importantly, we observed that TREM-1 blockade with LR12 significantly reduced the expression of the senescence-relative protein, including p16, p21, p53, and γ-H2AX in the lungs of PF mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with pulmonary fibrosis, LR12 significantly reduced lung p53 expression.

    In plain wordsIn mice with lung fibrosis, LR12 reduced lung p53 expression.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung p53 expression
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    More importantly, we observed that TREM-1 blockade with LR12 significantly reduced the expression of the senescence-relative protein, including p16, p21, p53, and γ-H2AX in the lungs of PF mice.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with pulmonary fibrosis, LR12 significantly reduced lung γ-H2AX expression.

    In plain wordsIn mice with lung fibrosis, LR12 reduced lung γ-H2AX expression.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung γ-H2AX expression
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    More importantly, we observed that TREM-1 blockade with LR12 significantly reduced the expression of the senescence-relative protein, including p16, p21, p53, and γ-H2AX in the lungs of PF mice.
  9. 09LabIn vitro (cells)Efficacy outcome

    In MLE12 cells, prophylactic or therapeutic TREM-1 blockade protected against senescence induced by bleomycin or hydrogen peroxide.

    In plain wordsIn cells, TREM-1 blockade protected against aging changes induced by bleomycin or hydrogen peroxide.

    Peptide
    Nangibotide
    Outcome
    DecreaseCell senescence
    Study

    mousen: not reported in source

    MLE12 murine alveolar epithelial cells
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, prophylactic or therapeutic blockade of TREM-1 protected MLE12 cells from senescence induced by BLM or H2O2.
    2 context sentences
    Summary · context
    Herein, we report that the prophylactical blockade of TREM-1 using a decoy peptide dodecapeptide (LR12) exerted protective effects against BLM-induced PF in mice, with a higher survival rate, attenuated tissue injury, and less extracellular matrix deposition.
    Summary · context
    In vitro, activating TREM-1 with an agonistic antibody exacerbated BLM-induced senescence in MLE12 cells, a murine AEC cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.