Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.

Konstantinopolsky MA, Chernyakova IV, Kolik LG

Bulletin of experimental biology and medicine1 Oct 2022Cited by 2 (Europe PMC)

PMID36322304DOI10.1007/s10517-022-05624-xPepBankPUB-36322304

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, a single dose of Selank reduced the total index of morphine withdrawal syndrome by 39.6% compared with the active control group.
In plain wordsIn rats dependent on morphine, Selank reduced withdrawal signs by 39.6% compared with the control group.
Peptide
Selank
Outcome
DecreaseTotal index of morphine withdrawal syndrome
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Active control group
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Measurements
Reduction of total withdrawal index
39.6%
Selank 0.3 mg/kg
Source sentences
Summary
Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230401
02AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, Selank significantly attenuated convulsive reactions compared with the active control group.
In plain wordsIn rats dependent on morphine, Selank reduced convulsions during withdrawal compared with the control group.
Peptide
Selank
Outcome
DecreaseConvulsive reactions during morphine withdrawal
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Active control group
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230402
03AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, Selank significantly attenuated ptosis compared with the active control group.
In plain wordsIn rats dependent on morphine, Selank reduced drooping eyelids during withdrawal compared with the control group.
Peptide
Selank
Outcome
DecreasePtosis during morphine withdrawal
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Active control group
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230403
04AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, Selank significantly attenuated posture disorders compared with the active control group.
In plain wordsIn rats dependent on morphine, Selank reduced posture problems during withdrawal compared with the control group.
Peptide
Selank
Outcome
DecreasePosture disorders during morphine withdrawal
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Active control group
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
Summary
Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230404
05AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, Selank increased the tactile sensitivity threshold 9-fold compared with the active control group.
In plain wordsIn rats dependent on morphine, Selank raised the touch sensitivity threshold 9-fold compared with the control group.
Peptide
Selank
Outcome
IncreaseTactile sensitivity threshold
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Active control group
Outcome group
Pain · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Measurements
Tactile sensitivity threshold increase
9-fold
Selank 0.3 mg/kg
Source sentences
Summary
9-fold increased the tactile sensitivity threshold in morphine-dependent rats in comparison with the group of active control
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230405
06AnimalAnimal study (in vivo)Efficacy outcome
In morphine-dependent rats, Selank was slightly less active than diazepam 2 mg/kg: diazepam lowered the total withdrawal index by 49.3% and raised the sensitivity threshold 13-fold.
In plain wordsIn rats dependent on morphine, Selank worked slightly less well than diazepam against withdrawal signs.
Peptide
Selank
Outcome
DecreaseWithdrawal syndrome reduction compared with diazepam
Study
ratn: not reported in source
Naloxone-precipitated morphine withdrawal in morphine-dependent rats
Comparator
Diazepam 2 mg/kg
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
0.3 mg/kg · intraperitoneal · single injectionAs given in this study (rat).
Measurements
Reduction of total withdrawal index
49.3%
diazepam 2 mg/kg
Sensitivity threshold increase
13-fold
diazepam 2 mg/kg
Source sentences
Summary
at the same time, Selank was slightly inferior to diazepam in a dose of 2 mg/kg by pharmacological activity (the decrease in total index of morphine withdrawal syndrome by 49.3% and 13-fold increase in sensitivity threshold).
1 context sentence(design, population, supporting numbers)
Summary · context
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.
Report a problemFND-3632230406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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