Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from rat.

Kondratenko RV, Povarov IS, Kolbaev SN, Derevyagin VI, Ostrovskaya RU, Gudasheva TA, Sharonova IN, Skrebitsky VG

Neuroscience letters3 Oct 2022

PMID36195298DOI10.1016/j.neulet.2022.136898PepBankPUB-36195298

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat hippocampal slices, noopept increased action potential firing frequency in CA1 stratum radiatum GABAergic interneurons.
In plain wordsIn lab tests of rat brain slices, noopept increased firing frequency in inhibitory neurons.
Peptide
Noopept (omberacetam)
Outcome
IncreaseInterneuron action potential firing frequency
Study
ratn: not reported in source
Rat hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5 µMAs given in this study (rat).
Source sentences
Summary
NP (5 µM) increased the action potential firing frequency recorded from GABAergic interneurons in the stratum radiatum (SR) of CA1 region.
1 context sentence(design, population, supporting numbers)
Summary · context
Currents were recorded from rat hippocampal neurons using the whole-cell, patch-clamp technique.
Report a problemFND-3619529801

Studies that did not test the peptide alone2

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

02LabNot a test of Noopept (omberacetam) aloneEx vivo tissueMechanism
In rat hippocampal slices, α7 receptor antagonists almost completely abolished the noopept-induced increase in interneuron firing frequency.
In plain wordsIn lab tests of rat brain slices, α7 receptor blockers almost completely blocked the increase in neuron firing induced by noopept.
Peptide
Noopept (omberacetam)
Outcome
Decreaseα7 receptor dependence of firing response
Study
ratn: not reported in source
Rat hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
This effect was almost completely abolished by the application of the α7 nAChR-selective antagonists α-bungarotoxin (α-BGT; 6 nM) and methyllycaconitine (MLA; 20 nM).
2 context sentences(design, population, supporting numbers)
Summary · context
NP (5 µM) increased the action potential firing frequency recorded from GABAergic interneurons in the stratum radiatum (SR) of CA1 region.
Summary · context
Currents were recorded from rat hippocampal neurons using the whole-cell, patch-clamp technique.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3619529802
03LabNot a test of Noopept (omberacetam) aloneEx vivo tissueMechanism
In rat hippocampal slices, α7 receptor antagonists eliminated the noopept-induced increase in spontaneous IPSC frequency in CA1 pyramidal cells.
In plain wordsIn lab tests of rat brain slices, α7 receptor blockers eliminated the increase in inhibitory current frequency induced by noopept.
Peptide
Noopept (omberacetam)
Outcome
Decreaseα7 receptor dependence of spontaneous IPSC response
Study
ratn: not reported in source
Rat hippocampal slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The increase in the frequency of spontaneous IPSCs in CA1 pyramidal cells induced by NP was also eliminated by α7 nAChRs antagonists.
1 context sentence(design, population, supporting numbers)
Summary · context
Currents were recorded from rat hippocampal neurons using the whole-cell, patch-clamp technique.
In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).
Report a problemFND-3619529803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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