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Study · Animal study (in vivo) · mouse · 2023

2 results

The Role of Endothelial Barrier Function in the Fibrosis of Salivary Gland.

Mao XD, Min SN, Zhu MQ, He L, Zhang Y, Li JW, Tian YX, Yu GY, Wu LL, Cong X

Journal of dental research12 Sept 2022Cited by 10 (Europe PMC)

PMID36112881 (opens in a new tab)DOI10.1177/00220345221118508 (opens in a new tab)PepBankPUB-36112881
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ligated submandibular glands, AT1001 significantly attenuated endothelial barrier disruption.

    In plain wordsIn mice with ligated salivary gland ducts, AT1001 reduced endothelial barrier disruption.

    Peptide
    Larazotide
    Outcome
    DecreaseEndothelial barrier disruption
    Study

    mousen: not reported in source

    Submandibular gland duct ligation
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the TJ sealer AT1001 significantly attenuated the disrupted endothelial barrier function and thereby ameliorated the glandular fibrosis.
    1 context sentence
    Summary · context
    Here, by using a mouse model in which the main excretory duct of the submandibular gland (SMG) was ligated to induce inflammation and fibrosis, endothelial barrier function and TJ protein expression and distribution were examined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ligated submandibular glands, AT1001 ameliorated glandular fibrosis.

    In plain wordsIn mice with ligated salivary gland ducts, AT1001 reduced gland fibrosis.

    Peptide
    Larazotide
    Outcome
    DecreaseGlandular fibrosis
    Study

    mousen: not reported in source

    Submandibular gland duct ligation
    Outcome group
    Lung injury and fibrosis · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the TJ sealer AT1001 significantly attenuated the disrupted endothelial barrier function and thereby ameliorated the glandular fibrosis.
    1 context sentence
    Summary · context
    Here, by using a mouse model in which the main excretory duct of the submandibular gland (SMG) was ligated to induce inflammation and fibrosis, endothelial barrier function and TJ protein expression and distribution were examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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