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Study · In vitro (cells) · 2023

10 results

Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways.

Ghassemi-Barghi N, Ehsanfar Z, Mohammadrezakhani O, Ashari S, Ghiabi S, Bayrami Z

Inflammation10 Sept 2022Cited by 12 (Europe PMC)

PMID36085231 (opens in a new tab)DOI10.1007/s10753-022-01737-7 (opens in a new tab)PepBankPUB-36085231
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In kidney cell lines treated with cisplatin, ARA290 pretreatment significantly reduced DNA damage in the comet assay.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 pretreatment reduced DNA damage.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseDNA damage (comet assay)
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    The findings indicated that ARA290 significantly reduced the DNA damage parameters of comet assay and the frequency of micronuclei induced by cisplatin.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  2. 02LabIn vitro (cells)Efficacy outcome

    In kidney cell lines treated with cisplatin, ARA290 pretreatment significantly reduced the frequency of micronuclei.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 pretreatment reduced signs of chromosome damage.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMicronuclei frequency
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    The findings indicated that ARA290 significantly reduced the DNA damage parameters of comet assay and the frequency of micronuclei induced by cisplatin.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  3. 03LabIn vitro (cells)Mechanism

    In kidney cell lines treated with cisplatin, ARA290 reduced reactive oxygen species levels.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 lowered harmful reactive oxygen molecules.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseROS level
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Besides, ARA290 improved cisplatin-induced oxidative stress by reducing MDA/ROS levels and enhancing antioxidant enzyme levels.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  4. 04LabIn vitro (cells)Mechanism

    In kidney cell lines treated with cisplatin, ARA290 reduced malondialdehyde levels.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 lowered a marker of oxidative damage (MDA).

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMDA level
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Besides, ARA290 improved cisplatin-induced oxidative stress by reducing MDA/ROS levels and enhancing antioxidant enzyme levels.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  5. 05LabIn vitro (cells)Mechanism

    In kidney cell lines treated with cisplatin, ARA290 enhanced antioxidant enzyme levels.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 raised levels of antioxidant enzymes.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseAntioxidant enzyme levels
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Besides, ARA290 improved cisplatin-induced oxidative stress by reducing MDA/ROS levels and enhancing antioxidant enzyme levels.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  6. 06LabIn vitro (cells)Mechanism

    In kidney cell lines treated with cisplatin, ARA290 reduced levels of pro-inflammatory cytokines.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 lowered inflammatory signals.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreasePro-inflammatory cytokine levels
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    In addition, reduced levels of pro-inflammatory cytokines indicated that cisplatin-induced renal inflammation was mitigated upon the treatment with ARA290.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  7. 07LabIn vitro (cells)Efficacy outcome

    In kidney cell lines treated with cisplatin, ARA290 reduced cisplatin-induced apoptosis.

    In plain wordsIn kidney cells exposed to cisplatin, ARA290 reduced programmed cell death.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseApoptosis
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Besides, ARA290 ameliorates cisplatin-induced cell injury by antagonizing apoptosis.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  8. 08LabIn vitro (cells)Mechanism

    In kidney cell lines, gene and protein levels of TNFα, IL1β and IL6 were significantly lower with ARA290 plus cisplatin than with cisplatin alone.

    In plain wordsIn kidney cells, ARA290 plus cisplatin gave lower inflammatory gene and protein levels than cisplatin alone.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTNFα, IL1β and IL6 gene and protein levels
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Furthermore, the molecular findings indicated that gene and protein levels of TNFα, IL1β, IL6, Caspase-3, and Bax were significantly decreased and gene and protein levels of Bcl2 significantly increased in the ARA290 plus cisplatin group compared with the cisplatin group.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  9. 09LabIn vitro (cells)Mechanism

    In kidney cell lines, gene and protein levels of Caspase-3 and Bax were significantly lower with ARA290 plus cisplatin than with cisplatin alone.

    In plain wordsIn kidney cells, ARA290 plus cisplatin gave lower cell-death marker levels than cisplatin alone.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseCaspase-3 and Bax gene and protein levels
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Furthermore, the molecular findings indicated that gene and protein levels of TNFα, IL1β, IL6, Caspase-3, and Bax were significantly decreased and gene and protein levels of Bcl2 significantly increased in the ARA290 plus cisplatin group compared with the cisplatin group.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.
  10. 10LabIn vitro (cells)Mechanism

    In kidney cell lines, gene and protein levels of Bcl2 were significantly higher with ARA290 plus cisplatin than with cisplatin alone.

    In plain wordsIn kidney cells, ARA290 plus cisplatin gave higher levels of a cell-survival marker than cisplatin alone.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseBcl2 gene and protein levels
    Study

    n: not reported in source

    HEK-293 and ACHN cells treated with cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50-400 nMAs given in this study.

    Source sentences

    Summary
    Furthermore, the molecular findings indicated that gene and protein levels of TNFα, IL1β, IL6, Caspase-3, and Bax were significantly decreased and gene and protein levels of Bcl2 significantly increased in the ARA290 plus cisplatin group compared with the cisplatin group.
    1 context sentence
    Summary · context
    For this purpose, HEK-293 and ACHN cells were treated with ARA290 (50-400 nM) and cisplatin (2.5 μM) in pretreatment condition.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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