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Study · Not a test of the peptide alone · 2023

4 results

Effects of intranasal oxytocin and positive couple interaction on immune factors in skin wounds.

Ditzen B, Aguilar-Raab C, Winter F, Hernández C, Schneider E, Bodenmann G, Heinrichs M, Ehlert U, Läuchli S

Brain, behavior, and immunity2 Sept 2022Cited by 7 (Europe PMC)

PMID36058418 (opens in a new tab)DOI10.1016/j.bbi.2022.08.011 (opens in a new tab)PepBankPUB-36058418
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In healthy couples with suction blister wounds, TNF-α responses to wounding were not affected by group assignment (positive interaction or control, intranasal oxytocin or placebo).

    In plain wordsIn couples with small skin wounds, TNF-α responses did not change with group (couple interaction or control, oxytocin spray or placebo).

    Peptide
    Oxytocin
    Outcome
    No significant changeWound fluid TNF-α response
    Study

    n = 160

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    TNF-α responses to wounding were not affected from group assignment
    2 context sentences
    Summary · context
    In a 4-group design, 80 healthy couples (N = 160 individuals) received four standard dermal suction blister wounds and were randomized to instructed positive interaction/control and intranasal OT/placebo.
    Summary · context
    Unstimulated cytokines (IL-1β, IL-6, TNF-α) were assessed from wound liquid at 40 min, 105 min and 24 hrs after wounding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In healthy couples, group assignment (positive interaction or control, intranasal oxytocin or placebo) did not affect friendly or dominant behavior during the interaction.

    In plain wordsIn couples, the group they were put in (couple interaction or control, oxytocin spray or placebo) did not change friendly or dominant behavior.

    Peptide
    Oxytocin
    Outcome
    No significant changeFriendly and dominant behavior during interaction
    Study

    n = 160

    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    Overall, group assignment did not affect friendly or dominant behavior during the interaction sequence.
    2 context sentences
    Summary · context
    In a 4-group design, 80 healthy couples (N = 160 individuals) received four standard dermal suction blister wounds and were randomized to instructed positive interaction/control and intranasal OT/placebo.
    Summary · context
    Unstimulated cytokines (IL-1β, IL-6, TNF-α) were assessed from wound liquid at 40 min, 105 min and 24 hrs after wounding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In healthy couples with suction blister wounds, women in the positive interaction and intranasal oxytocin condition had the lowest wound fluid IL-1β levels.

    In plain wordsIn couples with small skin wounds, women given oxytocin spray plus positive couple interaction had the lowest IL-1β in wound fluid.

    Peptide
    Oxytocin
    Outcome
    DecreaseWound fluid IL-1β in women in the positive interaction and oxytocin condition
    Study

    n: not reported in source

    Comparator
    Other group assignments
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    IL-1β and IL-6 levels, however, were moderated by group assignment with lowest levels in women in the positive interaction and OT condition in IL-1 and highest levels in IL-6.
    2 context sentences
    Summary · context
    In a 4-group design, 80 healthy couples (N = 160 individuals) received four standard dermal suction blister wounds and were randomized to instructed positive interaction/control and intranasal OT/placebo.
    Summary · context
    Unstimulated cytokines (IL-1β, IL-6, TNF-α) were assessed from wound liquid at 40 min, 105 min and 24 hrs after wounding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In healthy couples with suction blister wounds, women in the positive interaction and intranasal oxytocin condition had the highest wound fluid IL-6 levels.

    In plain wordsIn couples with small skin wounds, women given oxytocin spray plus positive couple interaction had the highest IL-6 in wound fluid.

    Peptide
    Oxytocin
    Outcome
    IncreaseWound fluid IL-6 in women in the positive interaction and oxytocin condition
    Study

    n: not reported in source

    Comparator
    Other group assignments
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    IL-1β and IL-6 levels, however, were moderated by group assignment with lowest levels in women in the positive interaction and OT condition in IL-1 and highest levels in IL-6.
    2 context sentences
    Summary · context
    In a 4-group design, 80 healthy couples (N = 160 individuals) received four standard dermal suction blister wounds and were randomized to instructed positive interaction/control and intranasal OT/placebo.
    Summary · context
    Unstimulated cytokines (IL-1β, IL-6, TNF-α) were assessed from wound liquid at 40 min, 105 min and 24 hrs after wounding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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