Improved Muscle Regeneration into a Joint Prosthesis with Mechano-Growth Factor Loaded within Mesoporous Silica Combined with Carbon Nanotubes on a Porous Titanium Alloy.

Wei X, Chen Q, Bu L, Wan X, Jiao Z, Han Z, Zou D, Zheng J, Yang C

ACS nano2 Sept 2022Cited by 14 (Europe PMC)

PMID36053268DOI10.1021/acsnano.2c04591PepBankPUB-36053268

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In vivo, the MGF-loaded scaffold promoted growth of muscle, rather than fibrotic tissue, into the porous Ti alloy structure.
In plain wordsIn animals, the MGF-loaded scaffold promoted muscle growth into the implant instead of scar tissue.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMuscle growth rather than fibrotic tissue into the scaffold
Study
n: not reported in source
MGF-loaded porous Ti alloy scaffold in vivo
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, in vivo studies show that the scaffold promotes the growth of muscle, rather than fibrotic tissue, into the porous Ti alloy structure and improves muscle-derived mechanical properties, the migration of satellite cells, and possibly immunomodulation.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326807
02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In vivo, the MGF-loaded scaffold improved muscle-derived mechanical properties.
In plain wordsIn animals, the MGF-loaded scaffold improved the mechanical properties of the muscle that grew into it.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMuscle-derived mechanical properties
Study
n: not reported in source
MGF-loaded porous Ti alloy scaffold in vivo
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, in vivo studies show that the scaffold promotes the growth of muscle, rather than fibrotic tissue, into the porous Ti alloy structure and improves muscle-derived mechanical properties, the migration of satellite cells, and possibly immunomodulation.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326808
03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism
In vivo, the MGF-loaded scaffold improved the migration of satellite cells.
In plain wordsIn animals, the MGF-loaded scaffold improved the movement of muscle stem cells into the implant.
Peptide
MGF / PEG-MGF
Outcome
IncreaseSatellite cell migration
Study
n: not reported in source
MGF-loaded porous Ti alloy scaffold in vivo
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
Furthermore, in vivo studies show that the scaffold promotes the growth of muscle, rather than fibrotic tissue, into the porous Ti alloy structure and improves muscle-derived mechanical properties, the migration of satellite cells, and possibly immunomodulation.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326809
04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
The MGF-loaded coating improved myoblast adhesion in porous Ti alloy scaffolds.
In plain wordsIn cells, the MGF-loaded scaffold coating improved muscle cell attachment.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMyoblast adhesion on MGF-loaded scaffold
Study
n: not reported in source
Myoblasts on MGF-loaded porous Ti alloy scaffolds
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326802
05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
The MGF-loaded coating improved myoblast proliferation in porous Ti alloy scaffolds.
In plain wordsIn cells, the MGF-loaded scaffold coating improved muscle cell growth.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMyoblast proliferation on MGF-loaded scaffold
Study
n: not reported in source
Myoblasts on MGF-loaded porous Ti alloy scaffolds
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326803
06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
The MGF-loaded coating improved myogenic differentiation of myoblasts in porous Ti alloy scaffolds.
In plain wordsIn cells, the MGF-loaded scaffold coating improved muscle cell maturation.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMyogenic differentiation on MGF-loaded scaffold
Study
n: not reported in source
Myoblasts on MGF-loaded porous Ti alloy scaffolds
Outcome group
Muscle injury and repair · Musculoskeletal
Source sentences
Summary
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326804
07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Safety outcome
The MGF-loaded coating showed no cytotoxicity in myoblast cultures on porous Ti alloy scaffolds.
In plain wordsIn cells, the MGF-loaded coating was not toxic to muscle cells.
Peptide
MGF / PEG-MGF
Outcome
No significant changeCytotoxicity of MGF-loaded coating
Study
n: not reported in source
Myoblasts on MGF-loaded porous Ti alloy scaffolds
Outcome group
Adverse events · Musculoskeletal
Source sentences
Summary
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326805
08LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
The Akt/mTOR signaling pathway plays a key role in the myoblast adhesion, proliferation and differentiation response to the MGF-loaded coating.
In plain wordsIn cells, the Akt/mTOR pathway played a key role in the muscle cell response to the MGF-loaded coating.
Peptide
MGF / PEG-MGF
Outcome
Not applicableAkt/mTOR signaling in myoblast response
Study
n: not reported in source
Myoblasts on MGF-loaded porous Ti alloy scaffolds
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
The Akt/mTOR signaling pathway plays a key role in this process.
2 context sentences(design, population, supporting numbers)
Summary · context
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326806
09LabNot a test of MGF / PEG-MGF aloneIn vitro (cell-free)Other
The two-layered CNT and mesoporous silica coating showed excellent MGF loading and prolonged release through covalent bonding.
In plain wordsIn lab tests, the coating held a lot of MGF and released it slowly.
Peptide
MGF / PEG-MGF
Outcome
Not applicableMGF loading and release from the coating
Study
n: not reported in source
MGF-loaded CNT and mesoporous silica coating on porous Ti alloy
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
This two-layered coating exhibits a nanostructured topology, excellent MGF loading, and prolonged release performance via covalent bonding to improve myoblast adhesion, proliferation and myogenic differentiation in porous Ti alloy scaffolds without cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, a porous titanium (Ti) alloy scaffold coated with carbon nanotubes (CNTs) and mesoporous silica nanoparticles (MSNs) through electrophoretic deposition (EPD) was designed as a mechano-growth factor (MGF) carrier.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3605326801

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.