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Study · Animal study (in vivo) · mouse · 2022

5 results

Nonerythropoietic Erythropoietin Mimetic Peptide ARA290 Ameliorates Chronic Stress-Induced Depression-Like Behavior and Inflammation in Mice.

Xu G, Zou T, Deng L, Yang G, Guo T, Wang Y, Niu C, Cheng Q, Yang X, Dong J, Zhang J

Frontiers in pharmacology15 Aug 2022Cited by 10 (Europe PMC)

PMID36046815 (opens in a new tab)PMCIDPMC9421426 (opens in a new tab)DOI10.3389/fphar.2022.896601 (opens in a new tab)PepBankPUB-36046815
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Summary

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder. But the treatment of depression remains challenging. Anti-inflammatory treatments frequently produce antidepressant effects. EPO-derived helix-B peptide ARA290 has been reported to retain the anti-inflammatory and tissue-protective functions of EPO without erythropoiesis-stimulating effects. The effects of ARA290 on MDD remain elusive. This study established chronic unpredictable mild stress and chronic social defeat stress mouse models. Daily administration of ARA290 during chronic stress induction in two mouse models ameliorated depression-like behavior, similar to fluoxetine. With marginal effects on peripheral blood hemoglobin and red cells, ARA290 and fluoxetine reversed chronic stress-induced increased frequencies and/or numbers of CD11b+Ly6Ghi neutrophils and CD11b+Ly6Chi monocytes in the bone marrow and meninges. Furthermore, both drugs reversed chronic stress-induced microglia activation. Thus, ARA290 ameliorated chronic stress-induced depression-like behavior in mice through, at least partially, its anti-inflammatory effects.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In two mouse models of chronic stress, daily ARA290 ameliorated depression-like behavior, similar to fluoxetine.

    In plain wordsIn stressed mice, daily ARA290 reduced depression-like behavior, to a similar degree as fluoxetine.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseDepression-like behavior
    Study

    mousen: not reported in source

    Chronic unpredictable mild stress and chronic social defeat stress mouse models
    Comparator
    Fluoxetine
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · daily during chronic stress inductionAs given in this study (mouse).

    Source sentences

    Summary
    Daily administration of ARA290 during chronic stress induction in two mouse models ameliorated depression-like behavior, similar to fluoxetine.
    1 context sentence
    Summary · context
    This study established chronic unpredictable mild stress and chronic social defeat stress mouse models.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In stressed mice, ARA290 had marginal effects on peripheral blood hemoglobin and red cells.

    In plain wordsIn stressed mice, ARA290 changed blood hemoglobin and red cells only marginally.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changePeripheral blood hemoglobin and red cells
    Study

    mousen: not reported in source

    Chronic unpredictable mild stress and chronic social defeat stress mouse models
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · daily during chronic stress inductionAs given in this study (mouse).

    Source sentences

    Summary
    With marginal effects on peripheral blood hemoglobin and red cells
    1 context sentence
    Summary · context
    This study established chronic unpredictable mild stress and chronic social defeat stress mouse models.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, ARA290 reversed the chronic stress-induced increase of CD11b+Ly6G-high neutrophils in bone marrow and meninges.

    In plain wordsIn stressed mice, ARA290 reversed a stress-related rise in neutrophils, a type of immune cell.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseBone marrow and meningeal neutrophils
    Study

    mousen: not reported in source

    Chronic unpredictable mild stress and chronic social defeat stress mouse models
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · daily during chronic stress inductionAs given in this study (mouse).

    Source sentences

    Summary
    ARA290 and fluoxetine reversed chronic stress-induced increased frequencies and/or numbers of CD11b+Ly6Ghi neutrophils and CD11b+Ly6Chi monocytes in the bone marrow and meninges.
    1 context sentence
    Summary · context
    This study established chronic unpredictable mild stress and chronic social defeat stress mouse models.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, ARA290 reversed the chronic stress-induced increase of CD11b+Ly6C-high monocytes in bone marrow and meninges.

    In plain wordsIn stressed mice, ARA290 reversed a stress-related rise in monocytes, a type of immune cell.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseBone marrow and meningeal monocytes
    Study

    mousen: not reported in source

    Chronic unpredictable mild stress and chronic social defeat stress mouse models
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · daily during chronic stress inductionAs given in this study (mouse).

    Source sentences

    Summary
    ARA290 and fluoxetine reversed chronic stress-induced increased frequencies and/or numbers of CD11b+Ly6Ghi neutrophils and CD11b+Ly6Chi monocytes in the bone marrow and meninges.
    1 context sentence
    Summary · context
    This study established chronic unpredictable mild stress and chronic social defeat stress mouse models.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In stressed mice, ARA290 reversed chronic stress-induced microglia activation.

    In plain wordsIn stressed mice, ARA290 reversed stress-related activation of microglia, the brain's immune cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMicroglia activation
    Study

    mousen: not reported in source

    Chronic unpredictable mild stress and chronic social defeat stress mouse models
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · daily during chronic stress inductionAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, both drugs reversed chronic stress-induced microglia activation.
    1 context sentence
    Summary · context
    This study established chronic unpredictable mild stress and chronic social defeat stress mouse models.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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