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Study · Not a test of the peptide alone · 2022

1 result

Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons.

Hammerslag LR, Humburg BA, Malone SG, Beckmann JS, Saatman KE, Grinevich V, Bardo MT

Addiction biology1 Sept 2022Cited by 2 (Europe PMC)

PMID36001434 (opens in a new tab)PMCIDPMC9413367 (opens in a new tab)DOI10.1111/adb.13217 (opens in a new tab)PepBankPUB-36001434
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats with an oxytocin-promoter DREADD in the paraventricular nucleus, clozapine blocked the effect of the peer S+, but it did not in rats with a control virus.

    In plain wordsIn rats, switching on oxytocin-producing brain cells with a drug blocked the peer-triggered drug-seeking effect; control rats were not affected.

    Peptide
    Oxytocin
    Outcome
    DecreasePeer-induced reinstatement of cocaine seeking after clozapine activation of OT neurons
    Study

    ratn: not reported in source

    OTp-hM3Dq DREADD in the paraventricular hypothalamus
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition

    Source sentences

    Summary
    Clozapine blocked the effect of the peer S+ in rats receiving the OTp-hM3Dq DREADD virus, but not in rats receiving the control virus.
    1 context sentence
    Summary · context
    A third experiment injected male and female rats with OTp-hM3Dq DREADD or control virus into PVN and tested them for peer-induced reinstatement of cocaine seeking following clozapine (0.1 mg/kg).

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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