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Study · Randomized controlled trial · n = 86 · 2022

12 results

Value of Thymosin α1 Combined With Blood Purification to Increase Successful Rescues of Shock Patients.

Bai L, Qiu X, Ding X, Bai X, Huang W, Yang L, Shi X

Alternative therapies in health and medicine1 Oct 2022

PMID35951068 (opens in a new tab)PepBankPUB-35951068
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. 12 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 did not change preparation time before treatment.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification did not change preparation time before treatment.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changePreparation time before treatment
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 did not change symptom-onset-to-door time.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification did not change time from symptom onset to arrival at hospital.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSymptom-onset-to-door time
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 did not change the rescue success rate.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification did not change the rescue success rate.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeRescue success rate
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  4. 04HumanRandomized controlled trialSafety outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 did not change the incidence of adverse events.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification did not change how often adverse events happened.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeIncidence of adverse events
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  5. 05HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 shortened the duration of shock.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification shortened the time in shock.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseDuration of shock
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Intensive care and hospital outcomes · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  6. 06HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 shortened the stay in the intensive care unit.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification shortened the stay in intensive care.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLength of stay in the intensive care unit
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Intensive care and hospital outcomes · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  7. 07HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 gave a higher overall response rate.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification gave a higher response rate.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseOverall response rate
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The groups showed no significant differences in the preparation time before treatment, SOTD, rescue success rate, and incidence of adverse events (P > .05), while the intervention group showed a significantly shorter duration of shock and length stay in the ICU and a significantly higher overall res…
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  8. 08HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock, T-lymphocyte subsets improved in both groups after treatment, and the changes were greater with thymosin alpha‑1 plus blood purification.

    In plain wordsIn adults with septic shock, T-cell measures improved in both groups, and more with thymosin alpha‑1 plus blood purification.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedChange in T-lymphocyte subsets
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The research team observed significant improvements in the T-lymphocyte subsets, ICs, and myocardial function in both groups postintervention, but the changes in the intervention group were significantly greater (P < .05).
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  9. 09HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock, inflammatory cytokines improved in both groups after treatment, and the changes were greater with thymosin alpha‑1 plus blood purification.

    In plain wordsIn adults with septic shock, inflammation markers improved in both groups, and more with thymosin alpha‑1 plus blood purification.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedChange in inflammatory cytokines
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The research team observed significant improvements in the T-lymphocyte subsets, ICs, and myocardial function in both groups postintervention, but the changes in the intervention group were significantly greater (P < .05).
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  10. 10HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock, myocardial function improved in both groups after treatment, and the change was greater with thymosin alpha‑1 plus blood purification.

    In plain wordsIn adults with septic shock, heart function improved in both groups, and more with thymosin alpha‑1 plus blood purification.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedChange in myocardial function
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The research team observed significant improvements in the T-lymphocyte subsets, ICs, and myocardial function in both groups postintervention, but the changes in the intervention group were significantly greater (P < .05).
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  11. 11HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 did not change overall survival at follow-up.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification did not change overall survival at follow-up.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeOverall survival at one-year follow-up
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Follow-up results showed no significant differences in overall survival between the intervention and control groups (P > .05), but the average LC was significantly higher in the intervention group (P < .05).
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…
  12. 12HumanRandomized controlled trialEfficacy outcome

    In adults with septic shock receiving blood purification, adding thymosin alpha‑1 gave a higher average LC at follow-up.

    In plain wordsIn adults with septic shock, adding thymosin alpha‑1 to blood purification gave a higher average LC at follow-up.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAverage LC at follow-up
    Study

    n = 86

    Comparator
    Blood purification only
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but the average LC was significantly higher in the intervention group (P < .05).
    1 context sentence
    Summary · context
    The research team numbered the patients in sequence according to the admission time of the patients, and then randomly numbered them by the computer, and assigned participants to an intervention or a control group, with 43 participants in the intervention group receiving T-α1 plus BP therapy and 43…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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