Abaloparatide Enhances Fusion and Bone Formation in a Rabbit Spinal Arthrodesis Model.

Morse KW, Moore H, Kumagai H, Hahn W, Koo A, Meyers KN, Bouxsein ML, Brooks DJ, Lanske B, Iyer S, Cunningham M

Spine9 Aug 2022Cited by 7 (Europe PMC)

PMID35943233PMCIDPMC10024932DOI10.1097/brs.0000000000004452PepBankPUB-35943233

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, abaloparatide increased fusion rates to 100% versus 45% with saline.
In plain wordsIn rabbits, abaloparatide increased spinal fusion rates compared with saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseFusion rate by manual palpation
Study
rabbitn = 21
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Measurements
Fusion rate
100%
abaloparatide
Fusion rate
45%
control
Source sentences
Summary
Rabbits that received abaloparatide had a 100% (10/10) fusion rate compared with 45% (5/11) for controls ( P <0.02) as assessed by manual palpation.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323301
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide increased the mean radiographic fusion score versus controls.
In plain wordsIn rabbits, abaloparatide increased the X-ray fusion score compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseRadiographic fusion score
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Measurements
Mean fusion score
4.17 score
abaloparatide
Mean fusion score
3.39 score
control
Source sentences
Summary
Radiographic analysis determined an overall mean fusion score of 4.17±1.03 in the abaloparatide group versus 3.39±1.21 for controls ( P <0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323302
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide increased formed bone volume versus controls.
In plain wordsIn rabbits, abaloparatide increased new bone volume compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseBone volume
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Measurements
Bone volume
1209 mm 3
abaloparatide
Bone volume
551 mm 3
control
Source sentences
Summary
The abaloparatide group also had a greater volume of bone formed with a bone volume of 1209±543 mm 3 compared with 551±152 mm 3 ( P <0.001) for controls.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323303
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide increased adjacent-level trabecular bone volume fraction versus controls.
In plain wordsIn rabbits, abaloparatide increased the trabecular bone volume fraction near the fusion compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseAdjacent trabecular bone volume fraction
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
The abaloparatide group had significantly greater trabecular bone volume fraction and trabecular thickness and lower specific bone surface and connectivity density in the adjacent levels when compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323304
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide increased adjacent-level trabecular thickness versus controls.
In plain wordsIn rabbits, abaloparatide increased trabecular thickness near the fusion compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseAdjacent trabecular thickness
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
The abaloparatide group had significantly greater trabecular bone volume fraction and trabecular thickness and lower specific bone surface and connectivity density in the adjacent levels when compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323305
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide decreased adjacent-level specific bone surface versus controls.
In plain wordsIn rabbits, abaloparatide decreased specific bone surface near the fusion compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
DecreaseAdjacent specific bone surface
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
The abaloparatide group had significantly greater trabecular bone volume fraction and trabecular thickness and lower specific bone surface and connectivity density in the adjacent levels when compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323306
07AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide decreased adjacent-level connectivity density versus controls.
In plain wordsIn rabbits, abaloparatide decreased bone connectivity density near the fusion compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
DecreaseAdjacent connectivity density
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
The abaloparatide group had significantly greater trabecular bone volume fraction and trabecular thickness and lower specific bone surface and connectivity density in the adjacent levels when compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323307
08AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide did not change trabecular number versus controls.
In plain wordsIn rabbits, abaloparatide did not change trabecular number compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeTrabecular number
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
Abaloparatide treatment did not impact trabecular number or separation.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323308
09AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide did not change trabecular separation versus controls.
In plain wordsIn rabbits, abaloparatide did not change trabecular separation compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeTrabecular separation
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
Abaloparatide treatment did not impact trabecular number or separation.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323309
10AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide did not significantly change flexion biomechanics versus controls.
In plain wordsIn rabbits, abaloparatide did not significantly change flexion mechanics compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeFlexion biomechanics
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
There were no differences in biomechanical testing in flexion, extension, or lateral bending ( P >0.05) between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323310
11AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide did not significantly change extension biomechanics versus controls.
In plain wordsIn rabbits, abaloparatide did not significantly change extension mechanics compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeExtension biomechanics
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
There were no differences in biomechanical testing in flexion, extension, or lateral bending ( P >0.05) between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323311
12AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, abaloparatide did not significantly change lateral bending biomechanics versus controls.
In plain wordsIn rabbits, abaloparatide did not significantly change lateral bending mechanics compared with controls.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeLateral bending biomechanics
Study
rabbitn: not reported in source
Posterolateral spinal fusion
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneous dailyAs given in this study (rabbit).
Source sentences
Summary
There were no differences in biomechanical testing in flexion, extension, or lateral bending ( P >0.05) between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 24 skeletally mature New Zealand White male rabbits underwent bilateral posterolateral spine fusion.
Summary · context
Following surgery, the rabbits were randomized to receive either saline as control or abaloparatide subcutaneous injection daily.
Report a problemFND-3594323312

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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